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26 studies
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- Migraine / chronic headache
BOTOX® vs. XEOMIN® for Chronic Migraine
Comparing two injections to treat chronic migraine
📍 Naval Medical Center Camp Lejeune · Jacksonville, NC · Get directions →
Chronic migraine (CM) is a disabling disorder that sidelines active duty personnel and diminishes their quality of life. It affects 1.3% to 2.4% of the general population.
- Migraine / chronic headache
A Study of Eptinezumab in Pediatric Participants With Episodic Migraine
Testing whether eptinezumab lowers the number of days with episodic migraine in children
📍 Ki Health Partners LLC DBA New England Institute for Clinical Research · Stamford, CT · +14 more US sites · Get directions →
The main goal of this trial is to learn whether eptinezumab helps reduce the number of days with episodic migraine in pediatric participants.
- Migraine / chronic headache
Efficacy and Safety Study of Rimegepant for the Preventative Treatment of Migraine in Pediatric Subjects
Testing rimegepant versus placebo as a migraine prevention in kids
📍 The Belinga Clinic · Fort Smith, AR · +39 more US sites · Get directions →
The purpose of this study is to compare the efficacy and safety of rimegepant to placebo as a preventative treatment for migraine in children and adolescents ≥ 6 to \<18 years with episodic migraine.
- Migraine / chronic headache
A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years
Testing an oral medicine to track side effects and migraine changes in teens aged 12 to 17
📍 Rehabilitation and Neurological Services /ID# 270782 · Huntsville, AL · +30 more US sites · Get directions →
Migraine is a disease that most often causes moderate to severe headache on one side of the head. A migraine attack is a headache that may be accompanied by throbbing, nausea, vomiting, sensitivity to light and sound, or other symptoms.
- Migraine / chronic headache
A Study to Learn About the Study Medicine Called Rimegepant in Adolescents With Frequent Migraine
Testing rimegepant tablets in adolescents with frequent migraine
📍 Xenoscience Inc · Phoenix, AZ · +26 more US sites · Get directions →
The purpose of this study is to learn about the effect of a study medicine called rimegepant in adolescents who have frequent migraine attacks. Rimegepant is a tablet that dissolves when you put it on or under your tongue.
- Migraine / chronic headache
A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine
Testing whether elismetrep works and is safe for treating migraine attacks
📍 Central Research Associates, LLC (CRA) dba Flourish Research · Birmingham, AL · +39 more US sites · Get directions →
This is a double-blind, randomized, multicenter, outpatient evaluation of the efficacy, safety, and tolerability of elismetrep, as compared with placebo, in the acute treatment of migraine.
- Migraine / chronic headache
Study to Assess Adverse Events and Disease Activity of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Children and Adolescents (Ages 6-17)
Testing side effects and migraine symptom activity of a tablet for kids
📍 Rehabilitation & Neurological Services /ID# 229969 · Huntsville, AL · +39 more US sites · Get directions →
Migraine is a common neurological disorder typically characterized by attacks of throbbing, moderate to severe headache, often associated with nausea, vomiting, and sensitivity to light and sound. Migraine is extremely common and disabling in children.
- Heart / cardiovascular diseaseHigh blood pressure
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
Testing a drug taken with empagliflozin in adults with type 2 diabetes and heart disease
📍 Pinnacle Research Group, LLC · Anniston, AL · +39 more US sites · Get directions →
This study is open to adults with type 2 diabetes, high blood pressure, and cardiovascular disease. People can join the study if they have these conditions and do not have a history of heart failure.
- Migraine / chronic headache
Effectiveness of Magnesium in Addition to Prochlorperazine for the Treatment of Migraines
Testing whether adding magnesium to prochlorperazine reduces migraine pain
📍 Advocate Christ Medical Center Emergency Department · Oak Lawn, IL · Get directions →
The purpose of this research study is to find out if using magnesium in addition to prochlorperazine will help reduce your migraine pain.
- Migraine / chronic headache
Mechanistic Studies of Psilocybin in Headache Disorders
Testing how psilocybin may affect migraine headache symptoms
📍 VA Connecticut Healthcare System · West Haven, CT · Get directions →
In previous clinical trial work, the investigators observed lasting reductions in headache burden after limited dosing of psilocybin. This purpose of this study is to examine potential sources for this observed effect.
- Obesity / overweightHigh blood pressure
Cardiovascular Effects of Angiotensin-(1-7) in Obesity Hypertension
Testing whether angiotensin-(1-7) affects heart health in people with obesity and high blood
📍 Penn State Milton S. Hershey Medical Center · Hershey, PA · Get directions →
Obesity is a global health concern that is associated with high blood pressure and an increased risk for developing cardiovascular disease. The purpose of this study is to find out if the investigational drug angiotensin-(1-7) can improve cardiovascular health in people with obesity and high blood pressure.
- High blood pressure
A Study Comparing the Clinical Benefit of Finerenone Versus a Fixed Dose Combination (FDC) of Extended-Release Torsemide and Spironolactone in Patients With Hypertension and Chronic Kidney Disease
Comparing finerenone versus two-fluid pill combination for high blood pressure and chronic kidney
📍 Sarfez Pharmaceuticals, Inc. · Vienna, VA · Get directions →
A study Comparing the Clinical Benefit of Finerenone Versus a Fixed-Dose Combination (FDC) of Extended-Release Torsemide and Spironolactone in Patients with Hypertension and Chronic Kidney Disease.
- Migraine / chronic headache
Study of Oral Ubrogepant to Assess Adverse Events and Change in Disease Activity in Adult Participants With Menstrual Migraine
Testing an oral medicine for side effects and migraine activity in adults with menstrual migraine
📍 Central Research Associates /ID# 260161 · Birmingham, AL · +39 more US sites · Get directions →
A migraine is a moderate to severe headache typically on one side of the head. A migraine attack is a headache that may be accompanied by throbbing, nausea, vomiting, sensitivity to light and sound, or other symptoms.
- Migraine / chronic headache
A Study to Learn About the Study Medicine Called Rimegepant in Women When Used for Intermittent Prevention of Menstrual Migraine
Testing rimegepant around menstrual periods to prevent menstrual migraine
📍 Mayo Clinic Hospital · Phoenix, AZ · +31 more US sites · Get directions →
The purpose of this study is to evaluate the efficacy and safety of rimegepant when administered during the peri-menstrual period (PMP) for intermittent prevention of migraine in women who experience menstrual migraine attacks.
- Migraine / chronic headache
A Study With Eptinezumab in Adolescents (12-17 Years) With Chronic Migraine
Testing whether eptinezumab works better than placebo to reduce days with chronic migraine in teens
📍 Yale-New Haven Children's Hospital - PIN · New Haven, CT · +21 more US sites · Get directions →
To find out if eptinezumab is better than placebo (normal saline solution) in lowering the number of days with migraine in young people ages 12 to 17 with chronic migraine.
- Migraine / chronic headache
A Study With Eptinezumab in Children and Adolescents (6 to 17 Years) With Chronic or Episodic Migraine
Studying the long-term safety of a migraine treatment for ages 6–17
📍 Yale University School of Medicine · New Haven, CT · +19 more US sites · Get directions →
The main goal of the study is to assess the long-term safety of eptinezumab on children and adolescents ages 6 to 17 with chronic or episodic migraine.
- High blood pressureKidney disease
A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure
Testing the effects and safety of a drug combo on kidney and heart death in people with chronic
📍 Research Site · Fairhope, AL · +39 more US sites · Get directions →
International, Multicenter, Double-Blind, Placebo-Controlled and Event-driven study to assess efficacy, safety and Tolerability of Baxdrostat in combination with Dapagliflozin on renal outcomes and cardiovascular mortality in participants with chronic kidney disease and high blood pressure
- Obesity / overweightHigh blood pressure
Impact of Semaglutide Withdrawal on Cardiometabolic Profile and Physiology of Energy Balance: Recovery Effects After Semaglutide Termination
Studying what happens to heart health and weight after stopping a weight-loss drug in people with
📍 Leadership Sinai Centre for Diabetes · Toronto, Ontario · Get directions →
Semaglutide is a medication from the class of drugs called glucagon-like peptide-1 agonists that promote weight loss. There is little clinical data on the best strategy to achieve weight maintenance following weight reduction induced by semaglutide.
- Migraine / chronic headache
Does Nerve Block + Oral Dexamethasone Reduce Recurrence of Headache Within 72 Hrs?
Testing whether a nerve block plus steroid tablets lowers migraine headache return within 72 hours
📍 University Medical Center of El Paso · El Paso, TX · Get directions →
For some patients who come to the emergency department for treatment of a migraine headache, peripheral headache nerve blocks (PHNB) have proven to be an efficient and effective treatment for headache relief. Previous studies have demonstrated that adding steroids as an adjunct treatment to standard migraine treatment can reduce recurrence of headaches in the subsequent few days.
- Migraine / chronic headache
Randomized Study in Children and Adolescents With Migraine: Acute Treatment
Testing a medicine called BHV-3000 versus placebo for treating migraine attacks in children and
📍 Achieve Clinical Research, LLC d/b/a Accel Research Sites-Neurology and Neurodiagnostic of Alabama · Birmingham, AL · +39 more US sites · Get directions →
The purpose of this study is to test the safety and efficacy of BHV-3000 versus placebo in the acute treatment of moderate or severe migraine in children and adolescents.
- Migraine / chronic headache
Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of Migraine
Testing the long-term safety of a migraine medicine in children and teens
📍 Perseverance Research Center, LLC · Scottsdale, AZ · +38 more US sites · Get directions →
The purpose of this study is to test the long-term safety of rimegepant in the acute treatment of migraine in children and adolescents (≥ 6 to \< 18 years of age).
- Obesity / overweightHigh blood pressure
Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)
Studying how the nervous system controls blood pressure in obesity and high blood pressure
📍 University of Texas Southwestern Medical Center · Dallas, TX · Get directions →
The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function.
- Obesity / overweightHeart / cardiovascular diseaseHigh blood pressure
PRECISION-BP: Precision Chronopharamacotherapy Targeting NP-RAAS-BP Rhythm Axis
Testing timing of blood pressure medicines in people with obesity and high blood pressure
📍 University of Alabama at Birmingham · Birmingham, AL · Get directions →
Obese individuals have a higher prevalence of nocturnal hypertension and non-dipping blood pressure (BP). These conditions are associated with an increased risk of cardiovascular (CV) events and death.
- Migraine / chronic headache
A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atogepant Tablets in Pediatric Participants (6-17 Years of Age) With Episodic Migraine
Testing side effects and how migraine symptoms change with an oral medicine in children and teens
📍 Rehabilitation & Neurological Services /ID# 248517 · Huntsville, AL · +39 more US sites · Get directions →
A migraine is a moderate to severe headache on one side of the head. A migraine attack is a headache that may be accompanied by throbbing, nausea, vomiting, sensitivity to light and sound, or other symptoms.
- Migraine / chronic headache
A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Episodic Migraine
Testing injections to prevent episodic migraine by reducing monthly migraine days
📍 TrialSphere Corp, Merz Investigational Site #0010513 · Chandler, AZ · +39 more US sites · Get directions →
In this clinical trial, participants with episodic migraine will receive injections with Xeomin or Placebo into muscles of the head and neck. The purpose is to measure the change in monthly migraine days with Xeomin injections compared to Placebo injections.
- Migraine / chronic headache
A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine
Testing injections to see if they reduce monthly migraine days in people with chronic migraine
📍 TrialSphere Corp, Merz Investigational Site #0010513 · Chandler, AZ · +39 more US sites · Get directions →
In this clinical trial, participants with chronic migraine will receive injections with Xeomin or Placebo into muscles of the head and neck. The purpose is to measure the change in monthly migraine days with Xeomin injections compared to Placebo injections.