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11 studies
Recruiting now, in plain language. Every study is watched over by an independent ethics board.
- Kidney disease
Oral Intradialytic Amino Acid Supplementation to Vitalize End-stage Kidney Disease Patients on Hemodialysis
Testing amino acid supplements during hemodialysis for fatigue and thinking in end-stage kidney
📍 The University of Texas Health Science Center at San Antonio · San Antonio, TX · Get directions →
The study will test and compare the efficacy of a single essential amino acid valine with a combination of essential amino acids (EAA) supplement on fatigue, frailty, and cognitive function in end-stage kidney disease (ESKD) patients undergoing hemodialysis (HD) treatment.
- Crohn's / ulcerative colitis (IBD)
Statin Therapy in Primary Sclerosing Cholangitis (PSC): a Multi-omics Study
Studying how statin treatment affects biology in people with primary sclerosing cholangitis
📍 Stanford University · Stanford, CA · Get directions →
PSC is a liver disease that has no medical cure. Patients with PSC are at a greatly increased risk of cancer and infection.
- Crohn's / ulcerative colitis (IBD)
Effect of Statins on Crohn's Disease
Testing whether statins can reduce gut narrowing (strictures) in adults with Crohn’s disease
📍 Stanford University · Stanford, CA · Get directions →
The goal of this clinical trial is to learn if statins work to prevent strictures in adults with Crohn's disease. The main question it aims to answer is: * Can statins reduce the formation of strictures in participants with stricturing Crohn's disease?
- Type 2 diabetesHeart / cardiovascular disease
Acute and Chronic Effects of Oral Ketones in Subjects With HFrEF and Diabetes
Testing how drinking ketone drinks affects heart function in people with type 2 diabetes and heart
📍 University of Texas Health Science Center at San Antonio · San Antonio, TX · Get directions →
This study will provide insight into whether cardiac function changes with oral Ketone Esters (KE) administered to patients with Type 2 Diabetes Mellitus (T2DM) and Heart failure with reduced ejection fraction (HFrEF). Plasma ketones are avidly extracted by cardiac muscle and their uptake is not dependent upon insulin or influenced by insulin resistance.
- Crohn's / ulcerative colitis (IBD)
Cranberry and Gut Health in Crohn's Disease
Testing whether a cranberry supplement helps gut health in people with Crohn’s disease
📍 UMASS medical center · Worcester, MA · Get directions →
This study is investigating whether a cranberry-based dietary supplement, rich in polyphenols and fiber, can enhance gut health in individuals with Crohn's disease. People with Crohn's disease often have an imbalance in their gut microbiome (the community of bacteria in the gut).
- Kidney disease
Concomitant Renal and Urinary Bladder Allograft Transplantation
Testing whether transplanting a new kidney and bladder at the same time is possible for people with
📍 Mayo Clinic · Rochester, MN · +1 more US site · Get directions →
The purpose of this study is to establish if concomitant renal and vascularized urinary bladder allograft transplantation is feasible.
- Kidney disease
Feasibility Trial of Sodium-GLucose coTransporter 2 INhibitors in Pediatric Chronic KIDney DiSease
Testing whether a trial of SGLT2 inhibitors in youth with chronic kidney disease is feasible
📍 Ann & Robert H. Lurie Children's Hospital of Chicago · Chicago, IL · Get directions →
The goal of this study is to learn if a clinical trial of sodium-glucose co-transporter 2 inhibitors (SGLT2i) is possible in youth with chronic kidney disease (CKD). The investigators also plan to explore whether treatment with SGLT2i (Empagliflozin) helps improve risk factors for worsening kidney and heart disease.
- Type 2 diabetesKidney disease
Subclinical Primary Aldosteronism in Diabetes At-Risk for Kidney Disease
Testing whether people with type 2 diabetes have early hormone-related kidney risk
📍 Brigham and Women's Hospital · Boston, MA · Get directions →
The aim of this protocol is to assess the presence and severity of primary aldosteronism pathophysiology in patients with type 2 diabetes who have, or are at-risk for developing, chronic kidney disease.
- Sickle cell disease
Determination of Red Cell Survival in Sickle Cell Disease and Other Hemoglobinopathies Using Biotin Labeling
Measuring how long red blood cells last in sickle cell disease
📍 National Institutes of Health Clinical Center · Bethesda, MD · Get directions →
Background: Sickle cell disease (SCD) is an inherited disorder of the blood. SCD causes red blood cells (RBCs) to die early.
- Crohn's / ulcerative colitis (IBD)
68Ga-FAPI-46 PET/CT for Assessing Small Bowel Fibrostenosis in Crohn's Disease
Testing a scan to see early scarring in the small bowel in Crohn’s
📍 Mayo Clinic · Rochester, MN · Get directions →
This study is a prospective, case-control study evaluating whether the PET radiotracer 68Ga-FAPI-46 can detect fibrostenosing Crohn's disease in the small bowel. The goal is to determine whether areas of early or developing fibrosis ("pre-stricture" changes) demonstrate uptake of the tracer, which binds to fibroblast activation protein (FAP).
- Obesity / overweightHeart / cardiovascular diseaseHigh cholesterol
Akkermansia Muciniphilia and Metabolic Side Effects of ADT
Testing how Akkermansia gut bacteria relate to body and blood lipid changes in people with obesity
📍 London Health Sciences Centre - Victoria Hospital · London, Ontario · Get directions →
The overriding objectives of this study are: 1. Primary outcomes: 1.