Concomitant Renal and Urinary Bladder Allograft Transplantation
Recruiting · Rochester, Minnesota
Always free
Study care at no cost to you
For your time and travel
Many studies pay you back
Most need no insurance or papers
Legal status usually isn't required; we'll tell you each study's requirements
Interpreters available
Ask for your language
Your choice
Voluntary — you can stop anytime
What is this study?
The purpose of this study is to establish if concomitant renal and vascularized urinary bladder allograft transplantation is feasible.
It is , overseen by an independent and licensed medical staff.
Read the full clinical description
The purpose of this study is to establish if concomitant renal and vascularized urinary bladder allograft transplantation is feasible.
Who this study is looking for
In plain language, from the study's own rules. The study team confirms the full details with you — this isn't a final yes or no.
✅ You may be able to join if…
- •Are male or female between 1 and 60 years old.
- •Are willing and able to sign consent (or have a legally authorized representative) and children 6–17 years will provide assent as needed.
- •Have chronic kidney disease (CKD) caused by a bladder problem such as neurogenic bladder, lower urinary tract blockage, or other bladder disorders.
- •Have a medical need for a bladder transplant due to “hostile bladders” (for example, high end-filling pressure or other bladder test problems) and/or changes in the upper urinary tract in the last 12 months.
- •If a kidney transplant is being considered, have very low kidney function (estimated GFR ≤ 20 mL/min or dialysis), and can work with the transplant team requirements (including training for clean intermittent catheterization or already using it).
🚫 You may not be able to join if…
- •Are pregnant or breastfeeding, or plan pregnancy during the study, or are able to get pregnant and are not willing to use effective birth control with low failure rates.
- •Have any condition that makes general anesthesia unsafe due to severe heart, lung, nervous system, body metabolism, or rheumatologic disease.
- •Have a severe allergic reaction history to human blood products or materials of bovine origin.
- •Have a current positive TB skin test (PPD) unless they completed treatment for latent TB and have a negative chest X-ray at enrollment.
- •Have uncontrolled diabetes with HbA1c > 10, or have severe/uncontrolled heart or lung problems, or bleeding disorders, or have active untreated cancer (except localized non-melanoma skin cancer).
Are you a good fit?
Simplified highlights. The study team always confirms the full details with you.
- ✓Adults roughly 1–60
- ✓Have Kidney disease
- !Some conditions may not be a fit: Obesity / overweight, Heart / cardiovascular disease, High blood pressure
- !Not for people who are pregnant or breastfeeding
What to expect, step by step
- 1
Usually a few weeks
The study team checks whether the study is a good fit for you, with a visit and sometimes lab tests. You can ask any questions before deciding.
- 2
Treatment
If you join and choose to continue, you receive the study treatment and are watched closely by medical staff.
- 3
Follow-up
After treatment, the team checks on your health and confirms the visit schedule with you. You can leave the study at any point.
Has this treatment been tested before?
This is an early-stage study. The treatment has gone through laboratory and preliminary testing before being studied in people here.
What you need to know before you apply
What is this study testing?+
The purpose of this study is to establish if concomitant renal and vascularized urinary bladder allograft transplantation is feasible.
Is it safe? Who makes sure of that?+
This is an early study (Phase 1), focused mostly on safety. Every study is reviewed and monitored by an independent ethics board (called an IRB) whose job is to protect participants, and care is overseen by licensed medical staff. You'll be told the known risks before you agree to anything, and you can stop at any time.
Will I get a placebo instead of the real treatment?+
Some studies compare a treatment against a placebo (an inactive version), and some don't. If this one does, the study team will explain your chances of receiving the active treatment before you decide. Nothing is hidden from you.
Do I have to stop taking my current medications?+
It depends on the study. Some let you stay on your current medications and some ask you to adjust them. Never stop a medication on your own — the study team will review everything with you first.
Does it cost anything? Will I be paid?+
Study-related care is provided at no cost to you. Some studies also pay for your time; the coordinator can tell you if this one does. You should never be asked to pay to take part.
Do I need insurance? Will anyone ask about my immigration status?+
No. You do not need health insurance to take part in a research study, and you will not be asked about your immigration status to join. Taking part is about whether you're a medical fit for the study.
What if English isn't my first language?+
You have the right to understand everything before you agree. Study sites can often provide materials or an interpreter in your language — you can ask the coordinator for one.
Is my information private?+
Yes. Your health information is only shared with the study sites you choose to be contacted by, and only to help match and enroll you. It is never sold, and you can ask us to delete it at any time.
Some requirements (like specific lab values or timing) are confirmed directly by the study team, not by us.
Source: ClinicalTrials.gov · NCT04626167 · Locations: Minnesota