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11 studies
Recruiting now, in plain language. Every study is watched over by an independent ethics board.
- Obesity / overweightHigh cholesterol
Evaluation of Milk Polar Lipids in Dyslipidemic Adults With Abdominal Obesity
Testing whether daily milk polar lipids affect heart and metabolic risk in adults with belly fat and
📍 University of Connecticut · Storrs, CT · Get directions →
The major objective of this project is to examine whether daily consumption of milk polar lipids (MPLs) influences cardiometabolic risk factors.
- Kidney disease
Oral Intradialytic Amino Acid Supplementation to Vitalize End-stage Kidney Disease Patients on Hemodialysis
Testing amino acid supplements during hemodialysis for fatigue and thinking in end-stage kidney
📍 The University of Texas Health Science Center at San Antonio · San Antonio, TX · Get directions →
The study will test and compare the efficacy of a single essential amino acid valine with a combination of essential amino acids (EAA) supplement on fatigue, frailty, and cognitive function in end-stage kidney disease (ESKD) patients undergoing hemodialysis (HD) treatment.
- Type 2 diabetesHeart / cardiovascular disease
Acute and Chronic Effects of Oral Ketones in Subjects With HFrEF and Diabetes
Testing how drinking ketone drinks affects heart function in people with type 2 diabetes and heart
📍 University of Texas Health Science Center at San Antonio · San Antonio, TX · Get directions →
This study will provide insight into whether cardiac function changes with oral Ketone Esters (KE) administered to patients with Type 2 Diabetes Mellitus (T2DM) and Heart failure with reduced ejection fraction (HFrEF). Plasma ketones are avidly extracted by cardiac muscle and their uptake is not dependent upon insulin or influenced by insulin resistance.
- Kidney disease
Concomitant Renal and Urinary Bladder Allograft Transplantation
Testing whether transplanting a new kidney and bladder at the same time is possible for people with
📍 Mayo Clinic · Rochester, MN · +1 more US site · Get directions →
The purpose of this study is to establish if concomitant renal and vascularized urinary bladder allograft transplantation is feasible.
- Kidney disease
Feasibility Trial of Sodium-GLucose coTransporter 2 INhibitors in Pediatric Chronic KIDney DiSease
Testing whether a trial of SGLT2 inhibitors in youth with chronic kidney disease is feasible
📍 Ann & Robert H. Lurie Children's Hospital of Chicago · Chicago, IL · Get directions →
The goal of this study is to learn if a clinical trial of sodium-glucose co-transporter 2 inhibitors (SGLT2i) is possible in youth with chronic kidney disease (CKD). The investigators also plan to explore whether treatment with SGLT2i (Empagliflozin) helps improve risk factors for worsening kidney and heart disease.
- Migraine / chronic headache
Mechanistic Studies of Psilocybin in Headache Disorders
Testing how psilocybin may affect migraine headache symptoms
📍 VA Connecticut Healthcare System · West Haven, CT · Get directions →
In previous clinical trial work, the investigators observed lasting reductions in headache burden after limited dosing of psilocybin. This purpose of this study is to examine potential sources for this observed effect.
- Obesity / overweightHigh blood pressure
Cardiovascular Effects of Angiotensin-(1-7) in Obesity Hypertension
Testing whether angiotensin-(1-7) affects heart health in people with obesity and high blood
📍 Penn State Milton S. Hershey Medical Center · Hershey, PA · Get directions →
Obesity is a global health concern that is associated with high blood pressure and an increased risk for developing cardiovascular disease. The purpose of this study is to find out if the investigational drug angiotensin-(1-7) can improve cardiovascular health in people with obesity and high blood pressure.
- Type 2 diabetesKidney disease
Subclinical Primary Aldosteronism in Diabetes At-Risk for Kidney Disease
Testing whether people with type 2 diabetes have early hormone-related kidney risk
📍 Brigham and Women's Hospital · Boston, MA · Get directions →
The aim of this protocol is to assess the presence and severity of primary aldosteronism pathophysiology in patients with type 2 diabetes who have, or are at-risk for developing, chronic kidney disease.
- Obesity / overweightHeart / cardiovascular diseaseHigh cholesterol
Akkermansia Muciniphilia and Metabolic Side Effects of ADT
Testing how Akkermansia gut bacteria relate to body and blood lipid changes in people with obesity
📍 London Health Sciences Centre - Victoria Hospital · London, Ontario · Get directions →
The overriding objectives of this study are: 1. Primary outcomes: 1.
- Migraine / chronic headache
Does Nerve Block + Oral Dexamethasone Reduce Recurrence of Headache Within 72 Hrs?
Testing whether a nerve block plus steroid tablets lowers migraine headache return within 72 hours
📍 University Medical Center of El Paso · El Paso, TX · Get directions →
For some patients who come to the emergency department for treatment of a migraine headache, peripheral headache nerve blocks (PHNB) have proven to be an efficient and effective treatment for headache relief. Previous studies have demonstrated that adding steroids as an adjunct treatment to standard migraine treatment can reduce recurrence of headaches in the subsequent few days.
- Obesity / overweightHigh blood pressure
Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)
Studying how the nervous system controls blood pressure in obesity and high blood pressure
📍 University of Texas Southwestern Medical Center · Dallas, TX · Get directions →
The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function.