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38 studies
Recruiting now, in plain language. Every study is watched over by an independent ethics board.
- Migraine / chronic headache
BOTOX® vs. XEOMIN® for Chronic Migraine
Comparing two injections to treat chronic migraine
📍 Naval Medical Center Camp Lejeune · Jacksonville, NC · Get directions →
Chronic migraine (CM) is a disabling disorder that sidelines active duty personnel and diminishes their quality of life. It affects 1.3% to 2.4% of the general population.
- Anxiety
Study to Evaluate the Efficacy and Safety of VQW-765 for the On-Demand Treatment of Social Anxiety Disorder
Testing a single oral dose medicine versus placebo for social anxiety in adults
📍 Vanda Investigational Site · Phoenix, AZ · +30 more US sites · Get directions →
This is a multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of a single oral dose of VQW-765 compared to placebo in adults with social anxiety disorder.
- Migraine / chronic headache
A Study of Eptinezumab in Pediatric Participants With Episodic Migraine
Testing whether eptinezumab lowers the number of days with episodic migraine in children
📍 Ki Health Partners LLC DBA New England Institute for Clinical Research · Stamford, CT · +14 more US sites · Get directions →
The main goal of this trial is to learn whether eptinezumab helps reduce the number of days with episodic migraine in pediatric participants.
- Migraine / chronic headache
Efficacy and Safety Study of Rimegepant for the Preventative Treatment of Migraine in Pediatric Subjects
Testing rimegepant versus placebo as a migraine prevention in kids
📍 The Belinga Clinic · Fort Smith, AR · +39 more US sites · Get directions →
The purpose of this study is to compare the efficacy and safety of rimegepant to placebo as a preventative treatment for migraine in children and adolescents ≥ 6 to \<18 years with episodic migraine.
- DepressionAnxiety
Perinatal Depression & Anxiety (PDA) and Maternal Gut Microbiome
Studying how gut bacteria in pregnant people relates to depression and anxiety
📍 Sunnybrook Health Science Center · Toronto, Ontario · Get directions →
Perinatal depression and anxiety (PDA) are the leading causes of maternal mortality in developed countries. Women with a history of depression have a 20 fold higher risk of PDA at subsequent pregnancies.
- DepressionAnxiety
Nebulized Ketamine for the Treatment of Major Depressive Disorder
Testing a breathing mist of ketamine to reduce symptoms of major depression
📍 Maimonides Medical Center · Brooklyn, NY · Get directions →
This is a double-blind active placebo controlled clinical trial for individuals with moderate to severe depression. The purpose of this study is to assess if nebulized ketamine can reduce depressive symptoms.
- DepressionAnxiety
Integrating Inuit Knowledge Principles in Multi-Level Mental Health Clinical Trials
Testing whether eating more country foods and cultural activities help Inuit adults with depression
📍 Aqqiumavvik Society · Arviat, Nunavut · Get directions →
This study is looking at how eating more country foods affects mental health among Inuit men and women in Arviat, NU. The goal is to evaluate if eating more of these foods helps people feel less depressed or anxious, and whether being part of food-gathering and cultural activities also makes a difference.
- Eczema / atopic dermatitis
A Study of the Medicine Called Abrocitinib in Children 6 to Less Than 12 Years of Age With Moderate-to-Severe Eczema
Testing whether a medicine called abrocitinib helps children with eczema and is safe
📍 Cahaba Dermatology & Skin Health Center, LLC · Birmingham, AL · +9 more US sites · Get directions →
This research study is being conducted to find out if the test medicine, abrocitinib, improves eczema and is safe for children 6 to \<12 years of age who have moderate-to-severe eczema. Research study participants who meet the study criteria will be assigned by chance (like the flip of a coin) to receive either abrocitinib test medicine or placebo (pretend medicine that looks just like the test medicine) for 16 weeks.
- Migraine / chronic headache
A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years
Testing an oral medicine to track side effects and migraine changes in teens aged 12 to 17
📍 Rehabilitation and Neurological Services /ID# 270782 · Huntsville, AL · +30 more US sites · Get directions →
Migraine is a disease that most often causes moderate to severe headache on one side of the head. A migraine attack is a headache that may be accompanied by throbbing, nausea, vomiting, sensitivity to light and sound, or other symptoms.
- DepressionAnxiety
Creatine for Depressed Male and Female Methamphetamine Users
Testing whether creatine helps depression and anxiety in people who use meth
📍 Montana State University College of Nursing (Missoula campus) · Missoula, MT · Get directions →
* Assess the antidepressant/anxiolytic effect of creatine in male and female methamphetamine users * Assess creatine's effect on methamphetamine use * Assess the safety of creatine in male methamphetamine users with depression
- Migraine / chronic headache
A Study to Learn About the Study Medicine Called Rimegepant in Adolescents With Frequent Migraine
Testing rimegepant tablets in adolescents with frequent migraine
📍 Xenoscience Inc · Phoenix, AZ · +26 more US sites · Get directions →
The purpose of this study is to learn about the effect of a study medicine called rimegepant in adolescents who have frequent migraine attacks. Rimegepant is a tablet that dissolves when you put it on or under your tongue.
- Migraine / chronic headache
A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine
Testing whether elismetrep works and is safe for treating migraine attacks
📍 Central Research Associates, LLC (CRA) dba Flourish Research · Birmingham, AL · +39 more US sites · Get directions →
This is a double-blind, randomized, multicenter, outpatient evaluation of the efficacy, safety, and tolerability of elismetrep, as compared with placebo, in the acute treatment of migraine.
- Migraine / chronic headache
Study to Assess Adverse Events and Disease Activity of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Children and Adolescents (Ages 6-17)
Testing side effects and migraine symptom activity of a tablet for kids
📍 Rehabilitation & Neurological Services /ID# 229969 · Huntsville, AL · +39 more US sites · Get directions →
Migraine is a common neurological disorder typically characterized by attacks of throbbing, moderate to severe headache, often associated with nausea, vomiting, and sensitivity to light and sound. Migraine is extremely common and disabling in children.
- Anxiety
Clinical Trial to Evaluate the Efficacy and Safety of the Aurora® Digital Medical Device in Adult Patients With Moderate to Severe Generalized Anxiety Disorder
Testing a digital therapy device plus usual medicine vs usual medicine alone
📍 Servicios Especializados En Ensayos Clinicos, Seec, Sc · Mexico City, Mexico City · Get directions →
To evaluate the superiority of cognitive behavioral therapy using the Aurora® digital medical device + conventional drug treatment, compared to conventional drug treatment alone, in reducing anxiety symptoms, as assessed by the change in the GAD-7 scale at 12 weeks of treatment, relative to baseline.
- Migraine / chronic headache
Effectiveness of Magnesium in Addition to Prochlorperazine for the Treatment of Migraines
Testing whether adding magnesium to prochlorperazine reduces migraine pain
📍 Advocate Christ Medical Center Emergency Department · Oak Lawn, IL · Get directions →
The purpose of this research study is to find out if using magnesium in addition to prochlorperazine will help reduce your migraine pain.
- Eczema / atopic dermatitis
A Study to Assess Adverse Events and Change in Disease Activity Comparing Oral Upadacitinib to Subcutaneous Dupilumab in Children From 2 to Less Than 12 Years of Age With Moderate to Severe Atopic Dermatitis
Comparing side effects and disease activity between two eczema treatments in children
📍 Applied Research Center Of Arkansas /ID# 268547 · Little Rock, AR · +29 more US sites · Get directions →
Atopic dermatitis (AD) is a skin condition that may cause a rash and itching due to inflammation of the skin. Topical therapies applied over the skin may not be enough to control the AD in trial participants who require systemic anti-inflammatory treatment.
- Migraine / chronic headache
Mechanistic Studies of Psilocybin in Headache Disorders
Testing how psilocybin may affect migraine headache symptoms
📍 VA Connecticut Healthcare System · West Haven, CT · Get directions →
In previous clinical trial work, the investigators observed lasting reductions in headache burden after limited dosing of psilocybin. This purpose of this study is to examine potential sources for this observed effect.
- DepressionAnxiety
Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)
Testing a cognitive training program to see brain and thinking changes in people with depression or
📍 UC San Diego · San Diego, CA · Get directions →
The proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms. Participants will be randomly assigned to one of two groups.
- Eczema / atopic dermatitis
A Study to Investigate Safety and Efficacy of Tapinarof Cream, 1% in Participants Ages 3 Months to < 24 Months With Atopic Dermatitis
Testing safety and effectiveness of a 1% eczema cream in babies and toddlers
📍 AllerVie Clinical Research · Birmingham, AL · +36 more US sites · Get directions →
The purpose of this global Phase 3 clinical study is to investigate the safety and efficacy of tapinarof cream, 1% in participants ages 3 months to 23 months (inclusive) with atopic dermatitis.
- Eczema / atopic dermatitis
A Trial to Evaluate the Efficacy and Safety of Tralokinumab in Combination With Topical Corticosteroids in Children and Infants With Moderate-to-severe Atopic Dermatitis
Testing an injected medicine plus steroid creams for eczema in children and infants
📍 Leo Pharma Investigational site · Birmingham, AL · +14 more US sites · Get directions →
The purpose of this trial is to test whether treatment with tralokinumab (administered subcutaneous injections \[SC\]) in combination with topical corticosteroids (TCS) is safe and effective to treat moderate-to-severe atopic dermatitis (AD) in children and infants. This will be judged by a range of assessments that rate the severity and extent of atopic dermatitis and its symptoms, as well as general health status and quality of life.
- Eczema / atopic dermatitis
A Study of Upadacitinib in Adult Participants With Moderate-to-Severe Atopic Dermatitis and Inadequate Response to Dupilumab
Testing an anti-inflammatory medicine in adults with eczema who did not respond enough to dupilumab
📍 Cahaba Dermatology & Skin Health Center /ID# 263855 · Birmingham, AL · +39 more US sites · Get directions →
Atopic dermatitis (AD) is a skin condition that may cause a rash and itching due to inflammation of the skin. Therapies spread over the skin may not be enough to control the AD in trial participants who require systemic anti-inflammatory treatment.
- Anxiety
Cannabidiol-Assisted Learning for Managing Generalized Anxiety Disorder
Testing cannabidiol added to talk therapy for adults with generalized anxiety
📍 Wayne State University School of Medicine, Tolan Park Medical Building · Detroit, MI · Get directions →
This randomized, double-blind, placebo-controlled clinical trial investigates the use of Food and Drug Administration (FDA)-approved cannabidiol (EPIDIOLEX®) as an adjunct to cognitive behavioral therapy (CBT) in adults with generalized anxiety disorder (GAD). The study aims to evaluate whether cannabidiol-assisted CBT enhances emotion regulation via dorsomedial prefrontal cortex (dmPFC) activation and improves anxiety symptom outcomes compared to CBT with placebo.
- Migraine / chronic headache
Study of Oral Ubrogepant to Assess Adverse Events and Change in Disease Activity in Adult Participants With Menstrual Migraine
Testing an oral medicine for side effects and migraine activity in adults with menstrual migraine
📍 Central Research Associates /ID# 260161 · Birmingham, AL · +39 more US sites · Get directions →
A migraine is a moderate to severe headache typically on one side of the head. A migraine attack is a headache that may be accompanied by throbbing, nausea, vomiting, sensitivity to light and sound, or other symptoms.
- Eczema / atopic dermatitis
A Phase 3 Study of Rezpegaldesleukin (NKTR-358) for Patients ≥ 12 Years of Age With Moderate-to-Severe Atopic Dermatitis
Testing a new treatment for moderate to severe eczema in people 12+ years old
📍 Nektar Investigative Site · St. Petersburg, FL · Get directions →
This is an interventional, randomized, parallel group, treatment, Phase 3, double blind study to assess the effect of Rezpegaldesleukin in participants 12 years of age or older with moderate to severe atopic dermatitis, as compared to placebo. The estimated participant overall duration is approximately 15 months.
- Migraine / chronic headache
A Study to Learn About the Study Medicine Called Rimegepant in Women When Used for Intermittent Prevention of Menstrual Migraine
Testing rimegepant around menstrual periods to prevent menstrual migraine
📍 Mayo Clinic Hospital · Phoenix, AZ · +31 more US sites · Get directions →
The purpose of this study is to evaluate the efficacy and safety of rimegepant when administered during the peri-menstrual period (PMP) for intermittent prevention of migraine in women who experience menstrual migraine attacks.
- Migraine / chronic headache
A Study With Eptinezumab in Adolescents (12-17 Years) With Chronic Migraine
Testing whether eptinezumab works better than placebo to reduce days with chronic migraine in teens
📍 Yale-New Haven Children's Hospital - PIN · New Haven, CT · +21 more US sites · Get directions →
To find out if eptinezumab is better than placebo (normal saline solution) in lowering the number of days with migraine in young people ages 12 to 17 with chronic migraine.
- Anxiety
Feasibility Study of Oral Ketamine Versus Placebo for the Treatment of Anxiety in Patients With Pancreatic Cancer
Testing whether taking a mouth medicine works for anxiety in pancreatic cancer
📍 Cedars-Sinai Medical Center · Los Angeles, CA · Get directions →
This is a prospective, single center, double blind, randomized, crossover feasibility study of oral ketamine versus placebo for the treatment of anxiety in patients with pancreatic cancer currently receiving or within 12 weeks of receiving cancer targeted therapy. The primary objective is to determine the feasibility of enrolling subjects and treatment adherence.
- Migraine / chronic headache
A Study With Eptinezumab in Children and Adolescents (6 to 17 Years) With Chronic or Episodic Migraine
Studying the long-term safety of a migraine treatment for ages 6–17
📍 Yale University School of Medicine · New Haven, CT · +19 more US sites · Get directions →
The main goal of the study is to assess the long-term safety of eptinezumab on children and adolescents ages 6 to 17 with chronic or episodic migraine.
- Anxiety
Sleep, Dreaming, and Virtual Reality for Mental Health
Testing virtual reality and sleep or dreaming practices for anxiety
📍 Northwestern University · Evanston, IL · +1 more US site · Get directions →
People spend approximately one-third of their lives asleep, yet sleep is often underused as an opportunity to support psychological well-being. Contemplative traditions, including Tibetan Dream Yoga, have developed practices that use waking imagination and lucid dreaming to explore perception, awareness, and habitual patterns of thinking.
- Migraine / chronic headache
Does Nerve Block + Oral Dexamethasone Reduce Recurrence of Headache Within 72 Hrs?
Testing whether a nerve block plus steroid tablets lowers migraine headache return within 72 hours
📍 University Medical Center of El Paso · El Paso, TX · Get directions →
For some patients who come to the emergency department for treatment of a migraine headache, peripheral headache nerve blocks (PHNB) have proven to be an efficient and effective treatment for headache relief. Previous studies have demonstrated that adding steroids as an adjunct treatment to standard migraine treatment can reduce recurrence of headaches in the subsequent few days.
- Migraine / chronic headache
Randomized Study in Children and Adolescents With Migraine: Acute Treatment
Testing a medicine called BHV-3000 versus placebo for treating migraine attacks in children and
📍 Achieve Clinical Research, LLC d/b/a Accel Research Sites-Neurology and Neurodiagnostic of Alabama · Birmingham, AL · +39 more US sites · Get directions →
The purpose of this study is to test the safety and efficacy of BHV-3000 versus placebo in the acute treatment of moderate or severe migraine in children and adolescents.
- Migraine / chronic headache
Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of Migraine
Testing the long-term safety of a migraine medicine in children and teens
📍 Perseverance Research Center, LLC · Scottsdale, AZ · +38 more US sites · Get directions →
The purpose of this study is to test the long-term safety of rimegepant in the acute treatment of migraine in children and adolescents (≥ 6 to \< 18 years of age).
- Anxiety
Cannabidiol Effects on Learning and Anxiety
Testing how CBD affects fear learning and anxiety in college students
📍 University of Connecticut · Storrs, CT · Get directions →
To examine the extent to which Cannabidiol (CBD) enhances fear conditioning extinction in college undergraduates who show elevated social anxiety. Undergraduates who display elevated social anxiety on standard assessments will be recruited at the University of Connecticut.
- DepressionAnxiety
Combination Therapy for Treatment of Sleep Disturbance in Patients With Advanced Cancer
Testing combined sleep treatments to improve sleep and mood in people with advanced cancer
📍 MD Anderson Cancer Center · Houston, TX · Get directions →
To learn if Cognitive Behavior Therapy (called CBT), combined with either Bright Light Therapy (called BLT), methylphenidate, and/or melatonin, can help improve sleep and other related symptoms such as fatigue, anxiety, and depression in cancer patients. This is an investigational study.
- Migraine / chronic headache
A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atogepant Tablets in Pediatric Participants (6-17 Years of Age) With Episodic Migraine
Testing side effects and how migraine symptoms change with an oral medicine in children and teens
📍 Rehabilitation & Neurological Services /ID# 248517 · Huntsville, AL · +39 more US sites · Get directions →
A migraine is a moderate to severe headache on one side of the head. A migraine attack is a headache that may be accompanied by throbbing, nausea, vomiting, sensitivity to light and sound, or other symptoms.
- Eczema / atopic dermatitis
A Long-term Study of the Medicine Called Abrocitinib in Children Aged 2 Years and Older With Moderate to Severe Eczema
Testing the long-term safety and effects of liquid abrocitinib for eczema in children
📍 Cahaba Dermatology & Skin Health Center · Birmingham, AL · +6 more US sites · Get directions →
This 24-month study will assess the long-term safety and efficacy of liquid abrocitinib oral suspension with or without topical medications in children 2 years of age or older with moderate-to-severe atopic dermatitis. The study will enroll two groups: participants who have completed other abrocitinib studies and participants who have never participated in abrocitinib studies.
- Migraine / chronic headache
A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Episodic Migraine
Testing injections to prevent episodic migraine by reducing monthly migraine days
📍 TrialSphere Corp, Merz Investigational Site #0010513 · Chandler, AZ · +39 more US sites · Get directions →
In this clinical trial, participants with episodic migraine will receive injections with Xeomin or Placebo into muscles of the head and neck. The purpose is to measure the change in monthly migraine days with Xeomin injections compared to Placebo injections.
- Migraine / chronic headache
A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine
Testing injections to see if they reduce monthly migraine days in people with chronic migraine
📍 TrialSphere Corp, Merz Investigational Site #0010513 · Chandler, AZ · +39 more US sites · Get directions →
In this clinical trial, participants with chronic migraine will receive injections with Xeomin or Placebo into muscles of the head and neck. The purpose is to measure the change in monthly migraine days with Xeomin injections compared to Placebo injections.