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5 studies
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- Type 2 diabetesHeart / cardiovascular disease
Acute and Chronic Effects of Oral Ketones in Subjects With HFrEF and Diabetes
Testing how drinking ketone drinks affects heart function in people with type 2 diabetes and heart
📍 University of Texas Health Science Center at San Antonio · San Antonio, TX · Get directions →
This study will provide insight into whether cardiac function changes with oral Ketone Esters (KE) administered to patients with Type 2 Diabetes Mellitus (T2DM) and Heart failure with reduced ejection fraction (HFrEF). Plasma ketones are avidly extracted by cardiac muscle and their uptake is not dependent upon insulin or influenced by insulin resistance.
- Type 2 diabetes
Precision Dosing of Metformin in Youth With T2D
Comparing usual versus higher doses of metformin in teens with type 2 diabetes
📍 UCSF Benioff Children's Hospital Oakland, Pediatric Diabetes Clinic · Oakland, CA · +1 more US site · Get directions →
The purpose of this study to compare the typically prescribed dose of metformin (1000mg twice a day) with a higher dose of metformin (1350mg twice a day).
- Type 2 diabetesKidney disease
Subclinical Primary Aldosteronism in Diabetes At-Risk for Kidney Disease
Testing whether people with type 2 diabetes have early hormone-related kidney risk
📍 Brigham and Women's Hospital · Boston, MA · Get directions →
The aim of this protocol is to assess the presence and severity of primary aldosteronism pathophysiology in patients with type 2 diabetes who have, or are at-risk for developing, chronic kidney disease.
- Type 2 diabetes
Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction
Studying how autophagy affects blood vessel function in adults with type 2 diabetes
📍 Medical College of Wisconsin · Milwaukee, WI · Get directions →
The goal of this clinical trial is to examine the role of autophagy on microvascular function in adults with Type 2 Diabetes. The main question it aims to answer are: * Does presence of Type 2 Diabetes reduce autophagy and impair microvascular function?
- Type 2 diabetes
SGLT2i, Hepatic Glucose Production, and SNS
Testing how diabetes medicines affect ketones and blood sugar in type 2 diabetes
📍 Texas Diabetes Institute/UH · San Antonio, TX · Get directions →
In this study, PI will test the hypothesis that distinct mechanisms account for the SGLT2i-induced stimulation of ketogenesis and lipolysis versus endogenous (hepatic) glucose production in patients with type 2 diabetes (T2D) that the increases in ketone production and lipolysis can be prevented by concomitant administration of the thiazolidinedione pioglitazone. Principal Investigator (PI) will conduct five distinct experiments to test this hypothesis in patients with T2D.