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13 studies
Recruiting now, in plain language. Every study is watched over by an independent ethics board.
- Migraine / chronic headache
A Study to Investigate the Safety and Efficacy of MEDI0618 Compared to Placebo in Adult Participants With Episodic Migraine
Testing a medicine shot to treat episodic migraine vs placebo
📍 Flourish - Birmingham · Birmingham, AL · +15 more US sites · Get directions →
The purpose of this Phase 2 study is to evaluate the safety and efficacy of SC MEDI0618 compared to placebo in participants with episodic migraine.
- Migraine / chronic headache
Study of EVO756 in Adults With Migraine
Testing a medicine called EVO756 compared with placebo in adults with migraine
📍 CA Medical Clinic for Headache · Los Angeles, CA · +12 more US sites · Get directions →
This study will evaluate the efficacy and safety of EVO756 against placebo in adults with migraine.
- Migraine / chronic headache
Bilateral Middle Meningeal Artery Lidocaine Infusion for Chronic Debilitating Migraines
Testing lidocaine delivered into skull blood vessels to treat chronic migraines
📍 Neuroscience Institute at Great Neck · Great Neck, NY · Get directions →
The main purpose of this study is to evaluate the effectiveness of a new treatment in improving chronic migraine symptoms. This treatment involves a targeted lidocaine infusion into blood vessels in the skull to numb pain receptors, potentially leading to improvements in chronic migraine intensity, frequency, and duration.
- High cholesterol
A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have Hypercholesterolemia
Testing how safe and well weekly injections of alirocumab work for high cholesterol in adults
📍 Anaheim Clinical Trials · Anaheim, CA · +29 more US sites · Get directions →
This study is researching an experimental drug called alirocumab, referred to as "study drug". In the United States, alirocumab is approved for the treatment of hypercholesterolemia (high blood cholesterol levels).
- Migraine / chronic headache
Study Evaluating the Efficacy, Safety, and Tolerability of ASY202 (Dihydroergotamine Mesylate [DHE] Inhalation Powder Delivered Via a Multidose Dry Powder Inhaler) for the Acute Treatment of Migraine in Adult Patients
Testing an inhaled medicine and its placebo for treating migraine in adults
📍 Sunwise Clinical Research, Llc · Walnut Creek, CA · +2 more US sites · Get directions →
This study is testing an investigational inhaled migraine medication to see how well it works, how safe it is, and how well people tolerate it. Adults with migraine will receive both the study medication (ASY202) and a placebo (inactive treatment) at different times during the study.
- Migraine / chronic headache
A Study to Evaluate IPN10200 Safety and Efficacy in the Prevention of Episodic or Chronic Migraine in Adults
Testing the safety and effects of IPN10200 to prevent migraine in adults
📍 Central Research Associates · Birmingham, AL · +39 more US sites · Get directions →
A migraine is a headache with severe throbbing pain or a pulsating sensation, usually on one side of the head. It is often accompanied by feeling or being sick and a sensitivity to bright lights and sound.
- Migraine / chronic headache
Cannabis for the Prophylactic Treatment of Migraine
Testing whether cannabis lowers the frequency of chronic migraine
📍 CHAMP Research (Calgary Headache Assessment & Management Program) · Calgary, Alberta · Get directions →
This study will evaluate the efficacy and safety of cannabis for the treatment of chronic migraine headaches. Study subjects will be randomized to one of three groups: lower dose CBD, higher dose CBD or placebo.
- Migraine / chronic headache
Cannabis for Chronic Headaches in Adolescents: the CAN-CHA Trial
Testing cannabis for chronic migraines in adolescents
📍 University of British Columbia · Vancouver, British Columbia · Get directions →
Chronic headaches are a major cause of disability among adolescents. Cannabis products have supported the management of headaches in adults and may play a role in pediatric chronic pain.
- High cholesterolLupus (SLE)
IMPACT Study: IMProve Pregnancy in APS With Certolizumab Therapy
Testing certolizumab added to usual treatment to improve pregnancy in lupus and antiphospholipid
📍 Hospital for Special Surgery · New York, NY · +1 more US site · Get directions →
This treatment trial evaluates the addition of an anti-tumor necrosis factor-alpha drug, certolizumab, to usual treatment (a heparin agent and low-dose aspirin) in pregnant women with antiphospholipid syndrome (APS) and repeatedly positive tests for lupus anticoagulant (LAC) to determine if this regimen will improve pregnancy outcomes. All enrolled patients will receive certolizumab, and pregnancy outcomes will be compared to those of women with APS and repeatedly positive tests for LAC enrolled in a previous study by the investigators.
- High cholesterol
Liver Adiposity Effects on Pediatric Statin
Measuring how liver fat affects how children take and respond to statin
📍 Children's Mercy Hospital · Kansas City, MO · Get directions →
Single center, open-label, prospective investigation to quantify the effects hepatocellular fat has on hepatic statin transport and response in children and adolescents in obese and non-obese children and adolescents 8-21 years of age with normal, wild-type SLCO1B1 c.521TT genotype that are dosed rosuvastatin
- Migraine / chronic headache
Clinical Trial of Endoscopically Guided Injection of Exparel (Bupivacaine) for the Treatment of Craniofacial Pain
Testing an endoscopy-guided injection of a local numbing medicine for migraine pain
📍 Peter H Hwang · Stanford, CA · Get directions →
Exparel has a proven efficacy in providing pain relief for up to 72 hours with a single-dose administration at surgical sites. The study aims to evaluate the effectiveness of endoscopically-guided injection of Exparel (Bupivacaine) for the treatment of craniofacial pain.
- Migraine / chronic headache
Efficacy of Nerve Blocks for Episodic Migraine
Testing whether numbing scalp nerves can treat and prevent episodic migraine
📍 Mayo Clinic in Rochester · Rochester, MN · Get directions →
The purpose of this study is to see how well blocking two to ten of the scalp nerves (that give feeling to the scalp and are painful during migraine headaches) with bupivacaine anesthetic (numbing medication) and low dose methylprednisolone (cortisone-like medicine or steroid) work for treating and preventing migraines. Our hypothesis is that the pain of most episodic migraine headaches can be eliminated and prevented for months by blocking the nerves that give pain sensation during a migraine.
- Migraine / chronic headache
A Study to Learn About the Study Medicine Called Zavegepant (PF-07930207) in Children With a History of Migraine
Testing safety and how zavegepant is processed in children with migraine
📍 Arkansas Children's Hospital · Little Rock, AR · +12 more US sites · Get directions →
The purpose of the study is to learn about safety and how the body processes the study medicine called Zavegepant (PF-07930207) in children with a history of migraine. This study helps understand how the medicine is changed and removed from the body after taking it.