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4 studies
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- Type 2 diabetesHeart / cardiovascular disease
📍 University of Texas Health Science Center at San Antonio · San Antonio, TX · Get directions →
This study will provide insight into whether cardiac function changes with oral Ketone Esters (KE) administered to patients with Type 2 Diabetes Mellitus (T2DM) and Heart failure with reduced ejection fraction (HFrEF). Plasma ketones are avidly extracted by cardiac muscle and their uptake is not dependent upon insulin or influenced by insulin resistance.
- Sickle cell disease
📍 National Institutes of Health Clinical Center · Bethesda, MD · Get directions →
Background: Sickle cell disease (SCD) is an inherited disorder of the blood. SCD causes red blood cells (RBCs) to die early.
- Lupus (SLE)
📍 Hospital for Special Surgery · New York, NY · Get directions →
ONT01 is a drug that is being studied for the treatment of Lupus Nephritis (LN) and Systemic Lupus Erythematosus (SLE) and is not approved by the FDA. The purpose of this study is to better determine whether ONT01 is safe and tolerated by people with lupus nephritis or SLE.
- Obesity / overweightHeart / cardiovascular diseaseHigh cholesterol
📍 London Health Sciences Centre - Victoria Hospital · London, Ontario · Get directions →
The overriding objectives of this study are: 1. Primary outcomes: 1.