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9 studies
Recruiting now, in plain language. Every study is watched over by an independent ethics board.
- Crohn's / ulcerative colitis (IBD)
Statin Therapy in Primary Sclerosing Cholangitis (PSC): a Multi-omics Study
Studying how statin treatment affects biology in people with primary sclerosing cholangitis
📍 Stanford University · Stanford, CA · Get directions →
PSC is a liver disease that has no medical cure. Patients with PSC are at a greatly increased risk of cancer and infection.
- Crohn's / ulcerative colitis (IBD)
Effect of Statins on Crohn's Disease
Testing whether statins can reduce gut narrowing (strictures) in adults with Crohn’s disease
📍 Stanford University · Stanford, CA · Get directions →
The goal of this clinical trial is to learn if statins work to prevent strictures in adults with Crohn's disease. The main question it aims to answer is: * Can statins reduce the formation of strictures in participants with stricturing Crohn's disease?
- Asthma
Timely Administration of IV Magnesium Sulfate in Patients With a Moderate Asthma Exacerbation
Testing early IV magnesium sulfate for people with a moderate asthma flare
📍 Oklahoma Children's Hospital · Oklahoma City, OK · Get directions →
This study aims to identify whether early administration of magnesium sulfate in moderate asthma exacerbations can potentially avoid admission, decrease length of stay in the emergency department (ED), decrease length of stay (LOS) in the general hospital floor vs pediatric intensive care unit (PICU), and decrease the need for respiratory support.
- Multiple sclerosis (MS)
Entire-body PET Scans for Multiple Sclerosis
Testing whether whole-body PET scans can better track MS brain and nerve damage
📍 Brain Health Alliance · Ladera Ranch, CA · Get directions →
To evaluate whether an entire-body positron emission tomography (PET) scanner can be exploited to improve evaluation, monitoring and measurement of both peripheral and central demyelination in multiple sclerosis (MS) patients.
- Crohn's / ulcerative colitis (IBD)
Cranberry and Gut Health in Crohn's Disease
Testing whether a cranberry supplement helps gut health in people with Crohn’s disease
📍 UMASS medical center · Worcester, MA · Get directions →
This study is investigating whether a cranberry-based dietary supplement, rich in polyphenols and fiber, can enhance gut health in individuals with Crohn's disease. People with Crohn's disease often have an imbalance in their gut microbiome (the community of bacteria in the gut).
- Lupus (SLE)
Safety and Efficacy of ONT01 in Lupus
Studying whether ONT01 is safe and tolerated in people with lupus
📍 Hospital for Special Surgery · New York, NY · Get directions →
ONT01 is a drug that is being studied for the treatment of Lupus Nephritis (LN) and Systemic Lupus Erythematosus (SLE) and is not approved by the FDA. The purpose of this study is to better determine whether ONT01 is safe and tolerated by people with lupus nephritis or SLE.
- Crohn's / ulcerative colitis (IBD)
68Ga-FAPI-46 PET/CT for Assessing Small Bowel Fibrostenosis in Crohn's Disease
Testing a scan to see early scarring in the small bowel in Crohn’s
📍 Mayo Clinic · Rochester, MN · Get directions →
This study is a prospective, case-control study evaluating whether the PET radiotracer 68Ga-FAPI-46 can detect fibrostenosing Crohn's disease in the small bowel. The goal is to determine whether areas of early or developing fibrosis ("pre-stricture" changes) demonstrate uptake of the tracer, which binds to fibroblast activation protein (FAP).
- Multiple sclerosis (MS)
Effects of Ublituximab on Motor Functions in Multiple Sclerosis
Testing whether ublituximab changes walking and fall risk in people with relapsing multiple
📍 Georgia State University · Atlanta, GA · +1 more US site · Get directions →
The purpose of this study is to test if ublituximab changes walking functions and fall risk in people with relapsing multiple sclerosis (RMS). Twenty-five qualified people with RMS will undergo a 48-week ublituximab treatment.
- Multiple sclerosis (MS)
Assessment of Synaptic Density in MS
Testing brain imaging to measure synapse density in progressive MS
📍 Brigham and Women's Hospital · Boston, MA · Get directions →
The investigators propose to use the novel SV2a-PET ligand, \[F-18\]SDM-8 to assess synaptic density in progressive multiple sclerosis (PMS) (including primary progressive multiple sclerosis (PPMS) and secondary progressive multiple sclerosis (SPMS)), given its improved imaging characteristics and potential for large scale applicability. The specific aims of the study are: Aim 1: To compare the cortical and subcortical grey matter synaptic density in PMS patients, patients with relapsing-remitting MS (RRMS), and healthy subjects, using a novel \[F-18\] labeled synaptic density PET ligand, \[F-18\]SDM8, also known as \[F-18\]SynvesT-1.