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11 studies

Recruiting now, in plain language. Every study is watched over by an independent ethics board.

  • Migraine / chronic headache

    Rimegepant as Preemptive Treatment for Predictable Trigger-Induced Migraine in Adult Patients in the US

    Testing rimegepant taken before a known trigger to prevent predictable migraine

    📍 MedStar Health: Neurology at McLean · McLean, VA · Get directions →

    Single-center, open label, prospective study conducted at Medstar Georgetown Headache Center. Men and woman ≥ 18 years old that are diagnosed with migraine with or without aura for at least 1 year, who report a reliable migraine trigger.

    ✓ Study care freePhase 4Ages 18+Learn more →
  • Obesity / overweightHigh blood pressure

    Impact GLP-1 Agonists Following Bariatric

    Testing whether GLP-1 medicines after bariatric surgery affect weight and blood sugar

    📍 University of Missouri Hospital · Columbia, MO · Get directions →

    Glucagon-like peptide 1 (GLP-1) is a hormone that helps regulate blood glucose levels through improved insulin sensitivity and release of insulin from the pancreas, control hunger, induce satiety and plays a role in the metabolic health of a person. GLP-1 receptor agonists (GLP1-RAs) have been shown to be effective in achieving weight loss in patients with type 2 diabetes while improving blood glucose control.

    ✓ Study care freePhase 4Ages 18+Learn more →
  • Migraine / chronic headache

    A Comparison of Nurtec ODT to Maxalt MLT-ODT in Adult ED Patients With Migraine Headache

    Comparing a migraine medicine tablet that dissolves in the mouth to another for adults with migraine

    📍 Maimonides Medical Center · Brooklyn, NY · Get directions →

    Rimegepant (Nurtec) is an orally administered small molecule CGRP receptor antagonist with efficacy in the acute treatment of migraine. Rizatriptan benzoate (MAXALT), is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist.

    ✓ Study care freePhase 4Ages 18–65Learn more →
  • Obesity / overweightHigh blood pressure

    Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease

    Testing treatments to lower high pressure in liver veins in people with advanced liver disease and

    💵 May compensate

    📍 Cleveland Clinic Main Campus · Cleveland, OH · Get directions →

    Cirrhosis is a form of advanced liver disease that can lead to serious complications, especially when combined with severe obesity. Many patients with cirrhosis also develop a condition called clinically significant portal hypertension (CSPH), which is increased pressure in the veins of the liver.

    ✓ Study care freePhase 4Ages 18–70Learn more →
  • Migraine / chronic headache

    A Study to Learn About the Safety of Taking an Additional Dose of the Medicine Rimegepant in Adults With Migraine

    Testing how safe it is to take an extra dose of rimegepant for migraine

    📍 Hope Clinical Research · Canoga Park, CA · +6 more US sites · Get directions →

    Acute treatments for migraine may not provide sufficient pain relief after an initial dose, and a second dose of a given medication may be needed to fully abort an attack. International Headache Society (IHS) global practice recommendations for the Acute Treatment of Migraine suggest a second dose of the same medication within the recommended dose limit in people with headache relapse after successful initial treatment of a migraine attack.

    ✓ Study care freePhase 4Ages 18+Learn more →
  • Migraine / chronic headache

    Effectiveness and Tolerability of Zavegepant for Acute Migraine Treatment Among Those Using CGRP Targeting Preventive Medications

    Testing whether a migraine attack medicine works and is tolerated in people using preventive CGRP

    📍 Mayo Clinic in Arizona · Phoenix, AZ · Get directions →

    Zavegepant (Zavzpret) is approved for the acute treatment of migraine with or without aura in the US. The purpose of this study is to investigate the effectiveness and tolerability of zavegepant for the acute treatment of migraine attacks amongst participants who are using calcitonin gene-related peptide (CGRP) migraine preventive treatments.

    ✓ Study care freePhase 4Ages 18+Learn more →
  • Obesity / overweightType 2 diabetesHeart / cardiovascular disease

    Pioglitazone on Heart Failure in Type-2 Diabetes Mellitus Participants

    Testing the diabetes medicine pioglitazone in people with type 2 diabetes, obesity, and heart

    📍 Texas Diabetes Institute/UH · San Antonio, TX · Get directions →

    Our goal of the study is to learn the effects of the diabetes medication named Pioglitazone, in type-2 diabetic obese participants with Heart failure. The main question it aims to answer are: 1.

    ✓ Study care freePhase 4Ages 30–70Learn more →
  • Heart / cardiovascular diseaseDementia / Alzheimer's

    Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

    Testing whether lowering cholesterol in older adults affects heart and memory outcomes

    📍 University of Alabama at Birmingham · Birmingham, AL · +37 more US sites · Get directions →

    PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo.

    ✓ Study care freePhase 4Ages 75+Learn more →
  • Migraine / chronic headache

    Qudexy XR for the Prevention of Migraine in Children 6 to 11 Years Old

    Testing Qudexy XR to prevent migraine in children ages 6 to 11

    📍 Upsher-Smith Clinical Trial Site #5 · Birmingham, AL · +14 more US sites · Get directions →

    A Phase 4 study to evaluate Qudexy XR for the prevention of migraine in children 6 to 11 years of age.

    ✓ Study care freePhase 4Ages 6–11Learn more →
  • Type 2 diabetesHeart / cardiovascular disease

    Effect of Tirzepatide on Progression of Coronary Atherosclerosis Using MDCT

    Testing tirzepatide to see if it slows plaque buildup in heart arteries in people with type 2

    📍 Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center (The Lundquist Institute) · Torrance, CA · Get directions →

    A multi-center, randomized, double-blind, placebo-controlled, parallel-group phase IV Study evaluating the effects of tirzepatide on atherosclerotic plaque progression assessed by coronary computed tomography angiography (CCTA) in participants with a diagnosis of type II Diabetes (T2DM) and atherosclerosis.

    ✓ Study care freePhase 4Ages 40–80Learn more →
  • Migraine / chronic headache

    Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study

    Comparing three medicines to prevent migraine headaches

    📍 Northern Arizona Healthcare · Flagstaff, AZ · +34 more US sites · Get directions →

    This goal of this study is to compare three medications used for migraine preventive treatment. This study will compare atogepant, a newer migraine preventive medication, with two older preventive medications, topiramate and propranolol.

    ✓ Study care freePhase 4Ages 18–70Learn more →