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14 studies
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- Eczema / atopic dermatitis
Molecular Signatures of Cutaneous Dupilumab Response
Studying how dupilumab affects immune cells in eczema skin
📍 University of California, San Francisco · San Francisco, CA · Get directions →
This study examines the effect of IL4RA blockade with dupilumab on the immune cells of atopic dermatitis skin lesions.
- Eczema / atopic dermatitis
Dupilumab De-escalation in Pediatric Atopic Dermatitis
Testing whether stopping or lowering eczema treatment works for kids
📍 Johns Hopkins Univerisity · Baltimore, MD · Get directions →
This is a pilot investigator-blinded, randomized clinical trial to assess the feasibility of dupilumab treatment discontinuation or dose-reduction in children aged 1-17 years who have achieved sustained atopic dermatitis (AD) control on dupilumab.
- Dementia / Alzheimer's
Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's Disease
Studying whether ovarian hormones are linked to aging and Alzheimer’s risk in women
📍 Mayo Clinic · Jacksonville, FL · +1 more US site · Get directions →
The researchers are trying to determine whether ovarian hormones are associated with aging processes and with the risk of developing Alzheimer's disease in women.
- Eczema / atopic dermatitis
Lebrikizumab in Moderate-to-severe Atopic Dermatitis
Testing a medicine called lebrikizumab for long-term improvement in eczema
📍 Physioseq USA - CA · Folsom, CA · +1 more US site · Get directions →
This research is studying a drug already approved for the treatment of atopic dermatitis (AD). This research collects health-related information and blood and skin samples to understand if the study drug, lebrikizumab, leads to long-term improvement in AD skin.
- DepressionDementia / Alzheimer's
Aβ Dynamics in LLMD
Testing how treating depression may change brain markers linked to Alzheimer’s
📍 NYU Langone Health · New York, NY · +1 more US site · Get directions →
This study will examine the biological factors that may modulate the relationship between depression and the development of Alzheimer's disease (AD). Since the direction of causation between depression and the biological factors associated with AD is unknown, the only way to understand cause and associated risk is to treat the depressive symptoms and examine the effects on AD biomarkers.
- Eczema / atopic dermatitis
Ethnic Differences in Mechanisms of Action of Dupilumab
Studying how a common eczema treatment works differently by race
📍 University of Michigan · Ann Arbor, MI · Get directions →
Previous research has shown that Asian and African Americans are more likely to develop atopic dermatitis (AD) than their Caucasian counterparts. However, limited information is known about AD in Asian and African American populations because most molecular studies have focused on Caucasians with AD.
- Dementia / Alzheimer's
A Study of Zunveyl on Safety, Tolerability, Neuropsychiatric Symptoms, and Caregiver Distress in Alzheimer's Disease (RESOLVE)
Testing the safety and side effects of Zunveyl in people with mild to moderate Alzheimer’s
📍 Tekton Research Saint Louis Psychiatry · St Louis, MO · Get directions →
The primary purpose of this study is to evaluate the safety and tolerability of Zunveyl® over 12 weeks of routine clinical use in adults with mild to moderate Alzheimer's disease.
- Dementia / Alzheimer's
Lemborexant for Insomnia in a Patient With Dementia: An N-of-1 Trial
Testing a sleep medicine for insomnia symptoms in a person with dementia
📍 Nova Scotia Health · Halifax, Nova Scotia · Get directions →
Insomnia is a highly common, chronic disorder that is distressful for the patient but also for caregivers and can give rise to a heavy burden on the healthcare team. Sleeping aids like benzodiazepines and other sedatives (e.g., zolpidem, zopiclone) have been widely used to help treat insomnia.
- Dementia / Alzheimer'sParkinson's disease
Elucidating the Role of Cholinergic Degeneration in Cognitive Fluctuations in Lewy Body Dementia
Studying how nerve cell loss affects thinking ups and downs in Lewy body dementia
📍 Virginia Commonwealth University · Richmond, VA · Get directions →
The proposed study aims to address the critical gaps in understanding the mechanisms of CF (Cognitive Fluctuations) by leveraging recently emerged molecular biomarkers, advanced neuroimaging techniques to assess measures of cholinergic degeneration, and synchronous EEG and assessments of attention. One of the overarching innovations of study is combining all of these assessments into one integrated research plan
- Dementia / Alzheimer's
Nighttime Agitation and Restless Legs Syndrome in People With Alzheimer's Disease
Studying nighttime agitation and restless legs in people with Alzheimer’s
📍 The University of Texas at Austin · Austin, TX · Get directions →
Nighttime agitation in persons with Alzheimer's disease causes patient suffering, distresses caregivers, and often results in prescriptions for harmful antipsychotics. Effective treatments are lacking because of limited knowledge of the etiology of nighttime agitation.
- Heart / cardiovascular diseaseDementia / Alzheimer's
Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
Testing whether lowering cholesterol in older adults affects heart and memory outcomes
📍 University of Alabama at Birmingham · Birmingham, AL · +37 more US sites · Get directions →
PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo.
- Eczema / atopic dermatitis
Using Dupilumab to Improve Circadian Function, Sleep and Pruritus in Children With Moderate/Severe Atopic Dermatitis
Testing how dupilumab affects sleep, itching, and body clock in children with moderate to severe
📍 Lurie Children's Hospital/Northwestern University · Chicago, IL · Get directions →
Single center, prospective, Open label study of sleep, pruritus and circadian function pre/post 12-weeks of dupilumab treatment in children 6-17 years old
- Eczema / atopic dermatitis
Dupixent and Narrowband UVB for Atopic Dermatitis
Testing dupilumab plus narrowband UVB light for eczema over 24 weeks
📍 Eczema Treatment Center of New Jersey · East Windsor, NJ · Get directions →
24 weeks open-label study with dupilumab and narrowband UVB phototherapy three times weekly for 12 weeks followed by 12 weeks of dupilumab monotherapy.
- Dementia / Alzheimer'sParkinson's disease
Comparing Antipsychotic Medications in LBD Over Time
Comparing medicines to see which works better for hallucinations or delusions in Lewy body disease
📍 University Health System · San Antonio, TX · +1 more US site · Get directions →
The primary objective of this study is to determine whether treatment with pimavanserin or quetiapine is associated with a greater improvement in psychosis when used in a routine clinical setting to treat hallucinations and/or delusions due to Parkinson's disease (PD) or dementia with Lewy bodies (DLB) - collectively referred to as Lewy body disease (LBD).