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21 studies

Recruiting now, in plain language. Every study is watched over by an independent ethics board.

  • Obesity / overweightHigh cholesterol

    Evaluation of Milk Polar Lipids in Dyslipidemic Adults With Abdominal Obesity

    Testing whether daily milk polar lipids affect heart and metabolic risk in adults with belly fat and

    📍 University of Connecticut · Storrs, CT · Get directions →

    The major objective of this project is to examine whether daily consumption of milk polar lipids (MPLs) influences cardiometabolic risk factors.

    ✓ Study care freeEarly Phase 1Ages 18–70Learn more →
  • Migraine / chronic headache

    Rimegepant as Preemptive Treatment for Predictable Trigger-Induced Migraine in Adult Patients in the US

    Testing rimegepant taken before a known trigger to prevent predictable migraine

    📍 MedStar Health: Neurology at McLean · McLean, VA · Get directions →

    Single-center, open label, prospective study conducted at Medstar Georgetown Headache Center. Men and woman ≥ 18 years old that are diagnosed with migraine with or without aura for at least 1 year, who report a reliable migraine trigger.

    ✓ Study care freePhase 4Ages 18+Learn more →
  • Migraine / chronic headache

    A Study to Investigate the Safety and Efficacy of MEDI0618 Compared to Placebo in Adult Participants With Episodic Migraine

    Testing a medicine shot to treat episodic migraine vs placebo

    📍 Flourish - Birmingham · Birmingham, AL · +15 more US sites · Get directions →

    The purpose of this Phase 2 study is to evaluate the safety and efficacy of SC MEDI0618 compared to placebo in participants with episodic migraine.

    ✓ Study care freePhase 2Ages 18–70Learn more →
  • Migraine / chronic headache

    Study of EVO756 in Adults With Migraine

    Testing a medicine called EVO756 compared with placebo in adults with migraine

    📍 CA Medical Clinic for Headache · Los Angeles, CA · +12 more US sites · Get directions →

    This study will evaluate the efficacy and safety of EVO756 against placebo in adults with migraine.

    ✓ Study care freePhase 2Ages 18–64Learn more →
  • Migraine / chronic headache

    Mechanistic Studies of Psilocybin in Headache Disorders

    Testing how psilocybin may affect migraine headache symptoms

    📍 VA Connecticut Healthcare System · West Haven, CT · Get directions →

    In previous clinical trial work, the investigators observed lasting reductions in headache burden after limited dosing of psilocybin. This purpose of this study is to examine potential sources for this observed effect.

    ✓ Study care freeEarly Phase 1Ages 21–70Learn more →
  • Migraine / chronic headache

    A Comparison of Nurtec ODT to Maxalt MLT-ODT in Adult ED Patients With Migraine Headache

    Comparing a migraine medicine tablet that dissolves in the mouth to another for adults with migraine

    📍 Maimonides Medical Center · Brooklyn, NY · Get directions →

    Rimegepant (Nurtec) is an orally administered small molecule CGRP receptor antagonist with efficacy in the acute treatment of migraine. Rizatriptan benzoate (MAXALT), is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist.

    ✓ Study care freePhase 4Ages 18–65Learn more →
  • Migraine / chronic headache

    A Study to Learn About the Safety of Taking an Additional Dose of the Medicine Rimegepant in Adults With Migraine

    Testing how safe it is to take an extra dose of rimegepant for migraine

    📍 Hope Clinical Research · Canoga Park, CA · +6 more US sites · Get directions →

    Acute treatments for migraine may not provide sufficient pain relief after an initial dose, and a second dose of a given medication may be needed to fully abort an attack. International Headache Society (IHS) global practice recommendations for the Acute Treatment of Migraine suggest a second dose of the same medication within the recommended dose limit in people with headache relapse after successful initial treatment of a migraine attack.

    ✓ Study care freePhase 4Ages 18+Learn more →
  • Migraine / chronic headache

    Effectiveness and Tolerability of Zavegepant for Acute Migraine Treatment Among Those Using CGRP Targeting Preventive Medications

    Testing whether a migraine attack medicine works and is tolerated in people using preventive CGRP

    📍 Mayo Clinic in Arizona · Phoenix, AZ · Get directions →

    Zavegepant (Zavzpret) is approved for the acute treatment of migraine with or without aura in the US. The purpose of this study is to investigate the effectiveness and tolerability of zavegepant for the acute treatment of migraine attacks amongst participants who are using calcitonin gene-related peptide (CGRP) migraine preventive treatments.

    ✓ Study care freePhase 4Ages 18+Learn more →
  • Migraine / chronic headache

    Bilateral Middle Meningeal Artery Lidocaine Infusion for Chronic Debilitating Migraines

    Testing lidocaine delivered into skull blood vessels to treat chronic migraines

    📍 Neuroscience Institute at Great Neck · Great Neck, NY · Get directions →

    The main purpose of this study is to evaluate the effectiveness of a new treatment in improving chronic migraine symptoms. This treatment involves a targeted lidocaine infusion into blood vessels in the skull to numb pain receptors, potentially leading to improvements in chronic migraine intensity, frequency, and duration.

    ✓ Study care freePhase 2Ages 18–75Learn more →
  • High cholesterol

    A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have Hypercholesterolemia

    Testing how safe and well weekly injections of alirocumab work for high cholesterol in adults

    📍 Anaheim Clinical Trials · Anaheim, CA · +29 more US sites · Get directions →

    This study is researching an experimental drug called alirocumab, referred to as "study drug". In the United States, alirocumab is approved for the treatment of hypercholesterolemia (high blood cholesterol levels).

    ✓ Study care freePhase 2Ages 18–80Learn more →
  • Migraine / chronic headache

    📍 Sunwise Clinical Research, Llc · Walnut Creek, CA · +2 more US sites · Get directions →

    This study is testing an investigational inhaled migraine medication to see how well it works, how safe it is, and how well people tolerate it. Adults with migraine will receive both the study medication (ASY202) and a placebo (inactive treatment) at different times during the study.

    ✓ Study care freePhase 2Ages 18–65Learn more →
  • Migraine / chronic headache

    A Study to Evaluate IPN10200 Safety and Efficacy in the Prevention of Episodic or Chronic Migraine in Adults

    Testing the safety and effects of IPN10200 to prevent migraine in adults

    📍 Central Research Associates · Birmingham, AL · +39 more US sites · Get directions →

    A migraine is a headache with severe throbbing pain or a pulsating sensation, usually on one side of the head. It is often accompanied by feeling or being sick and a sensitivity to bright lights and sound.

    ✓ Study care freePhase 2Ages 18–80Learn more →
  • Migraine / chronic headache

    Cannabis for the Prophylactic Treatment of Migraine

    Testing whether cannabis lowers the frequency of chronic migraine

    📍 CHAMP Research (Calgary Headache Assessment & Management Program) · Calgary, Alberta · Get directions →

    This study will evaluate the efficacy and safety of cannabis for the treatment of chronic migraine headaches. Study subjects will be randomized to one of three groups: lower dose CBD, higher dose CBD or placebo.

    ✓ Study care freePhase 2Ages 25+Learn more →
  • Migraine / chronic headache

    Cannabis for Chronic Headaches in Adolescents: the CAN-CHA Trial

    Testing cannabis for chronic migraines in adolescents

    📍 University of British Columbia · Vancouver, British Columbia · Get directions →

    Chronic headaches are a major cause of disability among adolescents. Cannabis products have supported the management of headaches in adults and may play a role in pediatric chronic pain.

    ✓ Study care freePhase 2Ages 14–17Learn more →
  • Obesity / overweightHeart / cardiovascular diseaseHigh cholesterol

    Akkermansia Muciniphilia and Metabolic Side Effects of ADT

    Testing how Akkermansia gut bacteria relate to body and blood lipid changes in people with obesity

    📍 London Health Sciences Centre - Victoria Hospital · London, Ontario · Get directions →

    The overriding objectives of this study are: 1. Primary outcomes: 1.

    ✓ Study care freeEarly Phase 1Ages 18+MenLearn more →
  • Migraine / chronic headache

    Does Nerve Block + Oral Dexamethasone Reduce Recurrence of Headache Within 72 Hrs?

    Testing whether a nerve block plus steroid tablets lowers migraine headache return within 72 hours

    📍 University Medical Center of El Paso · El Paso, TX · Get directions →

    For some patients who come to the emergency department for treatment of a migraine headache, peripheral headache nerve blocks (PHNB) have proven to be an efficient and effective treatment for headache relief. Previous studies have demonstrated that adding steroids as an adjunct treatment to standard migraine treatment can reduce recurrence of headaches in the subsequent few days.

    ✓ Study care freeEarly Phase 1Ages 18–85Learn more →
  • High cholesterolLupus (SLE)

    IMPACT Study: IMProve Pregnancy in APS With Certolizumab Therapy

    Testing certolizumab added to usual treatment to improve pregnancy in lupus and antiphospholipid

    📍 Hospital for Special Surgery · New York, NY · +1 more US site · Get directions →

    This treatment trial evaluates the addition of an anti-tumor necrosis factor-alpha drug, certolizumab, to usual treatment (a heparin agent and low-dose aspirin) in pregnant women with antiphospholipid syndrome (APS) and repeatedly positive tests for lupus anticoagulant (LAC) to determine if this regimen will improve pregnancy outcomes. All enrolled patients will receive certolizumab, and pregnancy outcomes will be compared to those of women with APS and repeatedly positive tests for LAC enrolled in a previous study by the investigators.

    ✓ Study care freePhase 2Ages 18–40WomenLearn more →
  • Migraine / chronic headache

    Qudexy XR for the Prevention of Migraine in Children 6 to 11 Years Old

    Testing Qudexy XR to prevent migraine in children ages 6 to 11

    📍 Upsher-Smith Clinical Trial Site #5 · Birmingham, AL · +14 more US sites · Get directions →

    A Phase 4 study to evaluate Qudexy XR for the prevention of migraine in children 6 to 11 years of age.

    ✓ Study care freePhase 4Ages 6–11Learn more →
  • Migraine / chronic headache

    Clinical Trial of Endoscopically Guided Injection of Exparel (Bupivacaine) for the Treatment of Craniofacial Pain

    Testing an endoscopy-guided injection of a local numbing medicine for migraine pain

    📍 Peter H Hwang · Stanford, CA · Get directions →

    Exparel has a proven efficacy in providing pain relief for up to 72 hours with a single-dose administration at surgical sites. The study aims to evaluate the effectiveness of endoscopically-guided injection of Exparel (Bupivacaine) for the treatment of craniofacial pain.

    ✓ Study care freePhase 2Ages 18–80Learn more →
  • Migraine / chronic headache

    Efficacy of Nerve Blocks for Episodic Migraine

    Testing whether numbing scalp nerves can treat and prevent episodic migraine

    📍 Mayo Clinic in Rochester · Rochester, MN · Get directions →

    The purpose of this study is to see how well blocking two to ten of the scalp nerves (that give feeling to the scalp and are painful during migraine headaches) with bupivacaine anesthetic (numbing medication) and low dose methylprednisolone (cortisone-like medicine or steroid) work for treating and preventing migraines. Our hypothesis is that the pain of most episodic migraine headaches can be eliminated and prevented for months by blocking the nerves that give pain sensation during a migraine.

    ✓ Study care freePhase 2Ages 18+Learn more →
  • Migraine / chronic headache

    Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study

    Comparing three medicines to prevent migraine headaches

    📍 Northern Arizona Healthcare · Flagstaff, AZ · +34 more US sites · Get directions →

    This goal of this study is to compare three medications used for migraine preventive treatment. This study will compare atogepant, a newer migraine preventive medication, with two older preventive medications, topiramate and propranolol.

    ✓ Study care freePhase 4Ages 18–70Learn more →