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64 studies
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- COPD (chronic lung disease)
A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease
Testing two doses of a medicine versus placebo for COPD symptoms
📍 Research Site · Birmingham, AL · +39 more US sites · Get directions →
This Phase IIb dose-ranging study will evaluate the efficacy and safety of 2 different doses of AZD6793 compared with placebo tablets in participants with moderate to very severe chronic obstructive pulmonary disease.
- Crohn's / ulcerative colitis (IBD)
Autologous Stem Cell Transplant for Crohn's Disease
Testing a patient’s own stem cell transplant for Crohn’s disease
📍 Icahn School of Medicine at Mount Sinai · New York, NY · Get directions →
Crohn's Disease (CD) is an inflammatory bowel disease. It can lead to significant complications and discomfort in the stomach and intestines.
- Crohn's / ulcerative colitis (IBD)
Study of Tilpisertib Fosmecarbil in Participants With Moderately to Severely Active Ulcerative Colitis
Testing a medicine versus placebo for moderate to severe ulcerative colitis
📍 GI Alliance · Sun City, AZ · +38 more US sites · Get directions →
The goal of this study is to learn if tilpisertib fosmecarbil (formerly known as GS-5290) is effective and safe in treating participants with moderate to severe ulcerative colitis. The study will compare participants in different treatment groups treated with tilpisertib fosmecarbil with participants treated with placebo.
- Crohn's / ulcerative colitis (IBD)
A Continuation Study of TAK-279 in Adults With Ulcerative Colitis (UC) and Crohn's Disease (CD)
Testing a medicine to see how it works long term for Crohn’s or ulcerative colitis
📍 Woodholme Gastroenterology Associates · Glen Burnie, MD · +1 more US site · Get directions →
Crohn's Disease and Ulcerative Colitis are two types of inflammatory bowel disease (IBD), which is a serious, long-term condition in the gut (intestine) that can cause pain and swelling (inflammation) in the bowel. TAK-279 is a medicine which helps to block inflammation.
- COPD (chronic lung disease)
To Evaluate the Effect of EXPD-101/FXS7553 Compared With Placebo in Patients With COPD Over 52 Weeks of Treatment
Testing two doses of a daily medicine versus placebo in people with COPD over 52 weeks
📍 DM Clinical Research - Phoenix · Phoenix, AZ · +11 more US sites · Get directions →
This is a Phase 2 study of the efficacy, safety, tolerability and pharmacokinetics of two doses of EXPD-101 in participants with COPD. Study participants will be randomized to receive either study drug or placebo administered once daily for 52 weeks.
- Crohn's / ulcerative colitis (IBD)
Autologous Stem Cell Transplantation for Crohn's Disease
Testing stem cell treatment for severe Crohn's disease in teens and adults
📍 UPMC Prebyterian- Adult Gastroenterology · Pittsburgh, PA · +1 more US site · Get directions →
The objective of this study is to evaluate the safety and effectiveness of administering high-dose chemotherapy followed by infusion of autologous CD34-selected peripheral blood stem cells (PBSC) in pediatric and adult patients with severe Crohn's disease.
- Crohn's / ulcerative colitis (IBD)
LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis
Testing an oral medicine for adults with moderately to severely active ulcerative colitis
📍 Valleywise Health Medical Center · Phoenix, AZ · +39 more US sites · Get directions →
The main purpose of this study is to evaluate the safety and effectiveness of LY4268989 when compared to placebo in adult participants with moderately to severely active ulcerative colitis (UC). The study drug will be administered orally.
- Crohn's / ulcerative colitis (IBD)
An Open-Label, Proof of Consent Study of Vorinostat for the Treatment of Mdoerate-to-Severe Crohn s Disease and Maintenance Therapy With Ustekinumab
Testing vorinostat in people with moderate to severe Crohn’s disease and using ustekinumab to
📍 National Institutes of Health Clinical Center · Bethesda, MD · Get directions →
Background: Crohn s disease (CD) is an inflammatory bowel disease. It causes inflammation of the gut.
- Crohn's / ulcerative colitis (IBD)
Study of DISC-0974-201 in Participants With IBD and Anemia
Testing a study drug to see if it is safe and helpful for people with IBD and anemia
📍 One of a Kind Clinical Research Center, LLC · Scottsdale, AZ · +11 more US sites · Get directions →
This is a Phase 2, multicenter, randomized, double-blind placebo-controlled study of DISC-0974 to evaluate safety, tolerability, and efficacy in participants with IBD and anemia of inflammation.
- Crohn's / ulcerative colitis (IBD)
Selenium Supplementation in Moderate-Severely Active Ulcerative Colitis Patients Treated With Advanced Therapies
Testing whether selenium supplements can help people with ulcerative colitis
📍 Northwestern University · Chicago, IL · Get directions →
Micronutrient deficiencies are common in ulcerative colitis (UC). Selenium deficiency is associated with worse disease outcomes including disease flares and need for surgery.
- Crohn's / ulcerative colitis (IBD)
A Study to Investigate the Efficacy and Safety of SAR442970 in Adult Participants With Ulcerative Colitis
Testing different doses of an ulcerative colitis medicine versus placebo
📍 Investigational Site Number: 8400009 · Escondido, CA · +20 more US sites · Get directions →
This is a phase 2b, randomized, double-blind, 3-arm study for the treatment of Ulcerative Colitis. The primary objective of this study is to assess the efficacy of different doses of SAR442970 compared with placebo in participants with moderate to severe Ulcerative Colitis.
- Crohn's / ulcerative colitis (IBD)
A Master Protocol (IIBD): A Study of Multiple Drugs in Adults With Ulcerative Colitis or Crohn's Disease
Testing several medications for adults with ulcerative colitis or Crohn's disease
📍 Mayo Clinic in Arizona - Scottsdale · Scottsdale, AZ · +14 more US sites · Get directions →
Study IIBD is a master protocol that will support a collection of individual sub studies that share key design components. Participants will be assigned to the appropriate study prior to randomization to a treatment group.
- Crohn's / ulcerative colitis (IBD)
Amitriptyline for IBS-like Symptoms in Quiescent Crohn's Disease
Testing low-dose amitriptyline for stomach pain and bowel symptoms in Crohn’s disease when
📍 University of Michigan · Ann Arbor, MI · Get directions →
Many individuals with Crohn's disease continue to experience abdominal pain, bloating, or bowel habit changes even when their inflammation is controlled. Amitriptyline is a medication commonly used at low doses to treat irritable bowel syndrome (IBS) and abdominal pain.
- Crohn's / ulcerative colitis (IBD)
Treatment of Moderate to Severe Refractory Crohn's Disease
Testing different doses of a new treatment for Crohn’s disease
📍 Mayo Clinic Arizona · Scottsdale, AZ · +12 more US sites · Get directions →
This research study is testing an investigational research product called TRX103 as a possible treatment for individuals suffering from Crohn's Disease (CD). The primary purpose of this study is to learn how safe and effective different doses of TRX103 are when administered to individuals with CD.
- Crohn's / ulcerative colitis (IBD)
A Study to Evaluate Efficacy and Safety of MK-8690 in Participants With Moderately to Severely Active Ulcerative Colitis (MK-8690-002)
Testing whether MK-8690 works better than a placebo for ulcerative colitis
📍 Clinnova Research ( Site 1042) · Anaheim, CA · +8 more US sites · Get directions →
The purpose of this protocol is to evaluate the efficacy of MK-8690 in participants with moderately to severely active ulcerative colitis. The primary hypothesis is that MK-8690 is superior to placebo with respect to the proportion of participants achieving clinical remission per Modified Mayo Score at Week 12.
- High blood pressureCOPD (chronic lung disease)
Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH
Testing tadalafil to see if it improves shortness of breath in COPD with high blood pressure in the
📍 Rocky Mountain Regional VA Medical Center, Aurora, CO · Aurora, CO · +4 more US sites · Get directions →
The investigators will study whether the drug tadalafil improves shortness of breath in 126 Veterans with Chronic Obstructive Pulmonary Disease (COPD) and high blood pressure in the lungs. The investigators will also assess whether tadalafil improves quality of life, home daily physical activity, exercise endurance, the frequency of acute flares of COPD, blood pressure in the lungs, and lung function.
- Crohn's / ulcerative colitis (IBD)💵 May compensate
Treatment of UC With Novel Therapeutics
Testing an oral medicine to treat mild ulcerative colitis over 12 weeks
📍 Brigham and Women's Hospital · Chestnut Hill, MA · Get directions →
This study is a clinical trial being done to investigate the efficacy of drug BRS201 as a treatment in patients with active mild ulcerative colitis. Participation in this study will take 12 weeks long and the study is structured as a crossover study in which participants will take the study drug for 4 weeks and a placebo drug for 4 weeks in a randomized order in the form of an oral medication.
- Crohn's / ulcerative colitis (IBD)💵 May compensate
Study of Novel Therapeutics for Acute Remedy of Colitis
Testing a new treatment in adults with acute ulcerative colitis
📍 Brigham and Women's Hospital · Chestnut Hill, MA · +1 more US site · Get directions →
This study is a clinical trial being done to investigate the efficacy of drug BRS201 as a treatment in patients with acute ulcerative colitis. Patients who qualify are adults who have not responded to treatments for their severe ulcerative colitis.
- Crohn's / ulcerative colitis (IBD)
Aquamin® for Prevention of Ulcerative Colitis J-Pouch-associate Intestinal Inflammation
Testing Aquamin to prevent inflammation of a J-pouch in ulcerative colitis
📍 University of Michigan · Ann Arbor, MI · Get directions →
Ulcerative colitis (UC) is a disease that causes long-term inflammation in the digestive tract, and many people with this condition require surgery to remove the colon and create a new J-pouch for stool. Some patients develop a problem called pouchitis, where this pouch becomes inflamed.
- Crohn's / ulcerative colitis (IBD)
Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active Crohn's Disease
Testing a medicine to treat moderate to severe Crohn’s disease when other treatments did not work
📍 IMC Gulf Coast Gastroenterology, PC · Fairhope, AL · +39 more US sites · Get directions →
This study has 3 treatment phases, a 12-Week Induction Phase, a 40-Week Maintenance Phase, and a 48-Week Extension Phase. The objective is to evaluate the efficacy and safety of obefazimod compared to placebo as induction and maintenance therapy in subjects with moderately to severely active CD after inadequate response (no response, loss of response, or intolerance) to conventional therapies and/or advanced therapies.
- Crohn's / ulcerative colitis (IBD)
A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease
Testing the safety of TAK-279 and whether it can reduce bowel inflammation in Crohn's disease
📍 United Medical Doctors · Murrieta, CA · +27 more US sites · Get directions →
Crohn's disease (CD) is a long-lasting condition causing inflammation that can affect any part of the gut. The purpose of this study is to evaluate the efficacy and safety of TAK-279 versus placebo in participants with moderately to severely active Crohn's disease (CD).
- COPD (chronic lung disease)
Rademikibart Add-on Treatment of an Acute COPD Exacerbation (Seabreeze STAT COPD)
Testing an add-on treatment for adults having a COPD flare with type 2 inflammation
📍 University of Alabama at Birmingham Lung Health Center · Birmingham, AL · +21 more US sites · Get directions →
This is a Phase 2, multicenter study in adult participants with an acute COPD exacerbation and type 2 inflammation
- Crohn's / ulcerative colitis (IBD)
A Study to Investigate Efficacy and Safety of SAR442970 in Patients With Crohn's Disease
Testing different doses of SAR442970 versus placebo for Crohn’s disease
📍 Investigational Site Number: 8400024 · Tucson, AZ · +19 more US sites · Get directions →
This is a phase 2b, randomized, double-blind, 3-arm study for the treatment of Crohn's disease. The primary objective of this study is to assess the efficacy of different doses of SAR442970 compared with placebo in participants with moderate to severe Crohn's disease.
- Crohn's / ulcerative colitis (IBD)
A Study to Evaluate Etrasimod Treatment in Adolescents With Ulcerative Colitis
Testing a medicine called etrasimod in teens with ulcerative colitis
📍 Arkansas Children's (IP Address) · Little Rock, AR · +19 more US sites · Get directions →
The purpose of this study is to determine the safety, efficacy, and pharmacokinetics (PK) of etrasimod for the treatment of moderately to severely active ulcerative colitis in adolescents (≥ 12 years up to \< 18 years of age). Participants who will complete the total 52-week treatment period will have the opportunity to continue in a Long-Term Extension (LTE) Period of up to 4 years (5 years after study enrollment).
- Crohn's / ulcerative colitis (IBD)
LFMT vs Placebo in New Biologic Start for Ulcerative Colitis
Testing whether a new biologic plus LFMT is better than placebo for ulcerative colitis
📍 University of Alberta Hospital · Edmonton, Alberta · Get directions →
To compare the safety and efficacy of concomitant LFMT versus placebo in UC patients who are starting vedolizumab or ustekinumab.
- Crohn's / ulcerative colitis (IBD)
Moving Beyond Inflammation as a Therapeutic Target for Crohn's Disease
Testing treatments for Crohn’s disease when inflammation in the small bowel is hard to control
📍 Cedars-Sinai Medical Center · Beverly Hills, CA · +2 more US sites · Get directions →
The purpose of this research study is to evaluate what type of treatment will be beneficial for people with Crohn's disease and difficult to treat inflammation in the small bowel. Current therapies are used to control the inflammation due to Crohn's disease in your digestive tract.
- Crohn's / ulcerative colitis (IBD)
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)
Testing a medicine against placebo in people with moderately to severely active ulcerative colitis
📍 Gastro Care Institute · Lancaster, CA · +7 more US sites · Get directions →
The purpose of this study is to evaluate the efficacy of RO7837195 compared with placebo in participants with moderately to severely active ulcerative colitis for whom prior treatment with conventional and/or advanced therapies has failed.
- Crohn's / ulcerative colitis (IBD)
A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis
Testing long-acting antibody treatments for adults with moderate to severe ulcerative colitis
📍 Site 024 · Canoga Park, CA · +24 more US sites · Get directions →
This is a Phase 2, multicenter, proof-of-concept platform study in adult participants with moderately to severely active ulcerative colitis (UC). The primary goal of the study is to assess the efficacy and safety of multiple interventions following intravenous (IV) induction and subcutaneous (SC) maintenance treatment.
- COPD (chronic lung disease)
A Phase IIb Ensifentrine-glycopyrrolate Fixed-dose Combination Dose Ranging Study in Subjects With COPD
Testing different doses of two inhaled medicines for COPD symptoms
📍 SEC Clinical Research, LLC · Dothan, AL · +39 more US sites · Get directions →
This study will assess the safety and efficacy of fixed dose combinations of ensifentrine with two different glycopyrrolate dose levels compared to placebo and to the individual components of the fixed dose combinations, each administered twice a day via standard jet nebulizer, in adult subjects with chronic obstructive pulmonary disease (COPD).
- Crohn's / ulcerative colitis (IBD)
A Phase 2 Study to Evaluate MORF-057 in Adults With Moderately to Severely Active Crohn's Disease
Testing different doses of MORF-057 in adults with Crohn’s disease
📍 Gastro Care Institute · Lancaster, CA · +23 more US sites · Get directions →
This is a Phase 2, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of 3 active dose regimens of MORF-057 in adult study participants with moderately to severely active Crohn's disease (CD).
- Lupus (SLE)Rheumatoid arthritisCrohn's / ulcerative colitis (IBD)
COVID-19 Booster and IIV Schedule in Immunocompromised Hosts
Testing COVID-19 booster and flu vaccine schedules in people with lupus, rheumatoid arthritis, or
📍 Maisonneuve -Rosemont Installation · Montreal, Quebec · Get directions →
The goal of this pragmatic embedded open-label, 2 x 2 factorial phase II randomized controlled trial is to evaluate strategies to improve COVID-19 booster and influenza vaccine immunogenicity in people living with immunocompromising conditions (PLIC). The main questions it aims to answer are: 1.
- COPD (chronic lung disease)
A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate to Severe Chronic Obstructive Pulmonary Disease
Testing how a study medicine affects safety and symptoms in people with COPD
📍 University of Alabama at Birmingham Lung Health Center · Birmingham, AL · +39 more US sites · Get directions →
The purpose of this clinical trial is to learn about the effects and safety of the study medicine PF-07275315 for the potential treatment of COPD. COPD is a condition that makes it difficult to breathe, which negatively impacts the quality of life and functioning of people who are affected.
- Obesity / overweightHigh blood pressureCOPD (chronic lung disease)
Feasibility of Semaglutide in Advanced Lung Disease
Testing whether semaglutide can be given safely to people with advanced lung disease
📍 University of Pennsylvania Perelman School of Medicine · Philadelphia, PA · Get directions →
The goal of this clinical trial is to learn whether semaglutide, an FDA-approved treatment for diabetes and obesity, is feasible and tolerable in patients with advanced lung disease. The main question\[s\] it aims to answer are: 1.
- Crohn's / ulcerative colitis (IBD)
HB-adMSCs for the Treatment of Crohn's Disease
Testing intravenous stem cell infusions vs placebo for Crohn's disease
📍 Hope Biosciences Research Foundation · Sugar Land, TX · Get directions →
Methodology: Randomized, double-blind, efficacy and safety study of allogeneic HB-adMSCs vs placebo for the treatment of Crohn's Disease with a 16-week treatment period and a safety and efficacy follow up period for 52 weeks post first treatment. Treatment Duration: 16 weeks General Objectives: To assess the efficacy and safety of multiple intravenous infusions of allogeneic HB-adMSCs by improving signs and symptoms of Crohn's Disease in this subject population.
- COPD (chronic lung disease)
A Study to Evaluate Solrikitug in Participants With COPD (ZION)
Testing solrikitug in people with COPD to check safety and effects
📍 University of Alabama at Birmingham Hospital · Birmingham, AL · +39 more US sites · Get directions →
A Randomized, Double-blind, Placebo-controlled, Multiple Dose-Ranging Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Solrikitug in Participants with Chronic Obstructive Pulmonary Disease (COPD).
- Crohn's / ulcerative colitis (IBD)
Beta-Hydroxybutyrate Feasibility Treating IBD
Testing whether taking a ketone supplement for 4 weeks is doable in people with Crohn’s disease
📍 University of Texas at Austin · Austin, TX · Get directions →
This clinical trial aims to understand the feasibility of patients taking ketone body supplement beta-hydroxybutyrate (BHB) for 4 weeks with a confirmed diagnosis of Crohn's disease and starting new therapy for active disease. The main questions it aims to answer are: * BHB supplementation will be feasible and acceptable to patients.
- Crohn's / ulcerative colitis (IBD)
Study of XmAb942 in Healthy Participants and Participants With Ulcerative Colitis
Testing the safety and effects of a drug called XmAb942 in ulcerative colitis
📍 Xencor Investigative Site · Scottsdale, AZ · +23 more US sites · Get directions →
Brief summary The Phase 1 study described herein will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of XmAb942 in healthy volunteers (Parts A and B). Part C of this study will be a Phase 2 study to evaluate XmAb942 in participants with ulcerative colitis (UC).
- Kidney diseaseCrohn's / ulcerative colitis (IBD)
Patient Preference for Subcutaneous vs. Intravenous Immune Therapy
Comparing patient preferences for skin injections vs IV for immune therapy in kidney disease or
📍 UPMC Hillman Cancer Center · Pittsburgh, PA · Get directions →
The study will evaluate patient and Health Care Professional- reported preference for Subcutaneous (SC) compared with IV nivolumab administration or similarly for SC compared with IV pembrolizumab.
- Crohn's / ulcerative colitis (IBD)
A Phase 2 Study to Evaluate Therapies for Inflammatory Bowel Disease
Testing treatments for inflammatory bowel disease in adults
📍 Mirador Therapeutics Selected Site · Birmingham, AL · +39 more US sites · Get directions →
This is a Phase 2, multicenter, platform study in adult participants with IBD (moderately to severely active Crohn's Disease or Ulcerative Colitis). The primary goal of this study is to assess the safety and efficacy of multiple investigational drugs.
- COPD (chronic lung disease)
A Study of WIN378 in Participants With Moderate to Severe COPD (Sirius)
Testing the right dose of a long-acting medicine for moderate to severe COPD
📍 WB Contracted Clinical Research Site · Miami Lakes, FL · +3 more US sites · Get directions →
This study is trying to identify the right dose of a long-acting medicine called WIN378 for people with moderate - severe chronic obstructive pulmonary disease (COPD). WIN378 blocks the action of a protein called TSLP that causes inflammation in the lung and may contribute to COPD control and symptoms.
- Crohn's / ulcerative colitis (IBD)
A Study of LY4395089 and Mirikizumab (LY3074828) Given Together and Mirikizumab (Alone) in Adults With Crohn's Disease
Testing an FXR medicine with or without mirikizumab in adults with Crohn's disease
📍 Mayo Clinic in Arizona - Scottsdale · Scottsdale, AZ · +14 more US sites · Get directions →
The main purpose of this study is to see how the safety and efficacy of a farnesoid X receptor (FXR) agonist (LY4395089), given together with mirikizumab compares with mirikizumab (alone) in adults with moderately to severely active Crohn's disease (CD). This study is part of the IIBD master protocol and will last approximately 62 weeks.
- Crohn's / ulcerative colitis (IBD)
LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:
Testing whether a new drug plus mirikizumab works and is safe for ulcerative colitis
📍 Mayo Clinic in Arizona - Scottsdale · Scottsdale, AZ · +39 more US sites · Get directions →
The main purpose of the study is to evaluate the effectiveness and safety of LY4268989 when given with mirikizumab compared to mirikizumab alone in adult participants with moderately to severely active ulcerative colitis (UC). Study participation will last approximately 118 weeks, including 104 weeks of treatment and may include up to 21 visits.
- Crohn's / ulcerative colitis (IBD)
A Study of Icotrokinra in Participants With Moderately to Severely Active Crohn's Disease
Testing how well and how safely icotrokinra works for Crohn's disease
📍 AZ Gastro Care · Chandler, AZ · +39 more US sites · Get directions →
The purpose of this study is to evaluate how-well icotrokinra works (clinical efficacy) and how safe it is (safety) in participants with moderately to severely active Crohn's disease (CD; a long-term condition causing severe inflammation of the intestinal tract).
- Crohn's / ulcerative colitis (IBD)
Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease
Testing targeted treatments for adults with moderate to severe Crohn’s disease
📍 Digestive Health Specialists /ID# 266216 · Dothan, AL · +39 more US sites · Get directions →
Crohn's disease (CD) is a long-lasting disease that causes severe inflammation (redness, swelling), in the digestive tract, most frequently affecting the bowels. It can cause many different symptoms including belly pain, diarrhea, tiredness, and weight loss.
- Crohn's / ulcerative colitis (IBD)
A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis
Testing how safe and effective two medicines are for adults with ulcerative colitis
📍 AZ Gastro Care - Chandler · Chandler, AZ · +39 more US sites · Get directions →
The main purpose of this study is to determine the safety and efficacy of eltrekibart and mirikizumab in adult participants with moderately to severely active ulcerative colitis (UC).
- Crohn's / ulcerative colitis (IBD)
Safety and Efficacy of OD-07656 and of Subsequent Vedolizumab Therapy in Moderately to Severely Active Ulcerative Colitis
Testing a medicine and then vedolizumab for people with ulcerative colitis
📍 Sunshine Coast University · Birtinya, · Get directions →
The purpose of this study is to evaluate the clinical efficacy and safety of OD-07656 in participants with moderately to severely active ulcerative colitis (UC). In addition, the study will evaluate the potential of OD-07656 to enhance the therapeutic benefit of vedolizumab when given after OD-07656.
- Crohn's / ulcerative colitis (IBD)
Low Dose IL-2 for the Treatment of Crohn's Disease
Testing low-dose interleukin-2 to find a safe dose for Crohn's disease
📍 Boston Children's Hospital · Boston, MA · +2 more US sites · Get directions →
The purpose of this study is to determine the safety and maximum effective dose (MED) of Interleukin-2 in subjects with moderate-to-severe crohn's disease.
- Crohn's / ulcerative colitis (IBD)
Standardized Microbiota Transplant Therapy in Crohn's Disease
Testing a standardized transplant of gut microbes for Crohn’s disease
📍 University of Minnesota · Minneapolis, MN · +1 more US site · Get directions →
Crohn's disease (CD) develops because of a disruption of homeostasis between the gut microbiota and the host immune system resulting in excessive inflammation in the intestinal tract. Current drug therapies for CD are directed at the immune system.
- Crohn's / ulcerative colitis (IBD)
A Study to Test Whether BI 3032950 Helps People With Ulcerative Colitis
Testing whether BI 3032950 helps adults with ulcerative colitis
📍 One of a Kind Clinical Research Center · Scottsdale, AZ · +13 more US sites · Get directions →
Adults between 18 and 80 years of age with ulcerative colitis can participate in this study. This is a study for people for whom previous treatment was not successful or who stopped previous treatment.
- Crohn's / ulcerative colitis (IBD)
A Study to Investigate Efficacy and Safety of SAR441566 in Patients With Crohn's Disease.
Testing different doses of SAR441566 for adults with Crohn’s disease
📍 GI Alliance - Arizona Digestive Health - Sun City- Site Number : 8400020 · Sun City, AZ · +18 more US sites · Get directions →
This is a phase 2, multinational, multicenter, randomized, double-blind, placebo-controlled, dose ranging study to evaluate the efficacy and safety of SAR441566 in adults with moderate to severe Crohn's Disease (CD). The primary objective of this study is to assess the efficacy of different doses of SAR441566 compared with placebo in participants with moderate to severe CD.
- COPD (chronic lung disease)
The Cardiovascular Consequences of Sleep Apnea Plus COPD (Overlap Syndrome)
Studying how sleep apnea together with COPD affects heart health
📍 UCSD Sleep Research · La Jolla, CA · Get directions →
Major progress has been made in the area of cardiovascular disease, but we believe that further progress will involve mechanistically addressing underlying respiratory causes including chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA). The most common cause of death in COPD is cardiovascular, although mechanisms are unknown.
- COPD (chronic lung disease)
Hyper Polarized Xenon-129 MRI vs Xenon-133 Scintigraphy
Comparing a lung scan that uses xenon MRI with a radioactive scan for COPD
📍 University of Virginia Health System · Charlottesville, VA · Get directions →
Hyper polarized Xenon-129 MRI will be directly compared to a radioactive Xe-133 scintigraphy to detect defects in lung ventilation from airflow limitation. This study is conducted as a pilot study with intention to conduct a larger clinical trial.
- COPD (chronic lung disease)
Lung and Bone Marrow Transplantation for Lung and Bone Marrow Failure
Testing whether lung transplant first can improve lung function before bone marrow transplant for
📍 UPMC Presbyterian · Pittsburgh, PA · +1 more US site · Get directions →
The purpose of this study is to determine whether a lung transplantation prior to bone marrow transplantation (BMT) would allow for restoration of pulmonary function prior to BMT, allowing to proceed to BMT, to restore hematologic function.
- Crohn's / ulcerative colitis (IBD)
Pilot and Feasibility Study of 2'-FL as a Dietary Supplement in IBD Patients Receiving Stable Maintenance Anti-TNF Therapy
Testing whether a supplement called 2'-FL is safe and well tolerated in IBD
📍 Connecticut Children's Medical Center · Hartford, CT · +2 more US sites · Get directions →
Randomized, placebo-controlled dose-ranging study of 2'-FL in IBD, Crohn's Disease (CD) and ulcerative colitis (UC). The overarching hypothesis is that 2'-FL supplementation in IBD will be safe and well tolerated, while increasing fecal Bifidobacterium abundance and butyrate in a dose dependent manner.
- Crohn's / ulcerative colitis (IBD)
Stem Cell Transplantation in Crohn's Disease
Testing stem cell transplant after high-dose immune treatment for severe Crohn's disease
📍 Cedars-Sinai Medical Center · Los Angeles, CA · Get directions →
Unfortunately, some patients with Crohn's disease (CD) fail to respond to the best clinical treatments and some only experience temporary benefit. For severe Crohn's disease, there is an experimental treatment called "high dose immunoablation" followed by autologous hematopoietic stem cell transplantation (HSCT).
- Crohn's / ulcerative colitis (IBD)
Evaluation the Safety and Efficacy of Lyophilized Fecal Microbiota Transplantation Administered Orally for Prevention of Relapse or Intestinal Inflammation in Adults With Ulcerative Colitis
Testing whether oral freeze-dried fecal transplant capsules help stop relapse or inflammation in
📍 The University of Texas Health Science Center at Houston · Houston, TX · Get directions →
The purpose of the study is to evaluate the efficacy and safety of lyophilized PRIM-DJ2727 capsules given orally in subjects with ulcerative colitis at remission stage. This study will also include longitudinal analyses of recipient's gut microbiota taxonomy and metagenomics to determine potential associations with clinical outcomes in context of active FMT or placebo administration.
- High blood pressureCOPD (chronic lung disease)
Pulmonary Hypertension SOLAR
Testing a noninvasive MRI pattern to study lung blood vessel changes in pulmonary hypertension
📍 Duke University Medical Center · Durham, NC · Get directions →
The main goal of this study is to develop a noninvasive signature for pulmonary vascular remodeling in Group 3 PH patients, using hyperpolarized 129Xe magnetic resonance imaging (129Xe MRI). Such a signature may identify Group 3 PH responders to PAH-specific therapies.
- COPD (chronic lung disease)
Oral Sildenafil for Exercise Capacity, Dyspnea and Cardiopulmonary Function in COPD
Testing sildenafil taken by mouth to improve exercise ability and breathing in people with COPD
📍 Clinical Physiology Laboratory · Edmonton, Alberta · Get directions →
Chronic obstructive pulmonary disease (COPD) is a condition characterized by airway obstruction. Patients with COPD experience significant shortness of breath on exertion.
- Crohn's / ulcerative colitis (IBD)
The Use of Butyrate Therapy in Pediatric Ulcerative Colitis
Testing butyrate enemas as a treatment for kids with ulcerative colitis
📍 Children's Hospital Los Angeles · Los Angeles, CA · Get directions →
Butyrate is an important metabolite produced by the gut microbiome and has been shown as a helpful therapy in ulcerative colitis. This is a feasibility study to determine the efficacy of butryate enemas in pediatric ulcerative colitis.
- COPD (chronic lung disease)
Effect of Ensifentrine on Sputum Markers of Inflammation in COPD
Testing whether nebulized ensifentrine changes lung inflammation markers in people with COPD
📍 University of Alabama at Birmingham · Birmingham, AL · +2 more US sites · Get directions →
This is a randomized, double-blind, placebo-controlled, two-period cross-over study of nebulized ensifentrine (3 mg) or placebo administered BID for two 8-week Treatment Periods. All participants with receive both ensifentrine and placebo during participation.
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