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7 studies
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- Type 2 diabetesHeart / cardiovascular disease
Acute and Chronic Effects of Oral Ketones in Subjects With HFrEF and Diabetes
Testing how drinking ketone drinks affects heart function in people with type 2 diabetes and heart
📍 University of Texas Health Science Center at San Antonio · San Antonio, TX · Get directions →
This study will provide insight into whether cardiac function changes with oral Ketone Esters (KE) administered to patients with Type 2 Diabetes Mellitus (T2DM) and Heart failure with reduced ejection fraction (HFrEF). Plasma ketones are avidly extracted by cardiac muscle and their uptake is not dependent upon insulin or influenced by insulin resistance.
- Multiple sclerosis (MS)
Entire-body PET Scans for Multiple Sclerosis
Testing whether whole-body PET scans can better track MS brain and nerve damage
📍 Brain Health Alliance · Ladera Ranch, CA · Get directions →
To evaluate whether an entire-body positron emission tomography (PET) scanner can be exploited to improve evaluation, monitoring and measurement of both peripheral and central demyelination in multiple sclerosis (MS) patients.
- Obesity / overweightHigh blood pressure
Cardiovascular Effects of Angiotensin-(1-7) in Obesity Hypertension
Testing whether angiotensin-(1-7) affects heart health in people with obesity and high blood
📍 Penn State Milton S. Hershey Medical Center · Hershey, PA · Get directions →
Obesity is a global health concern that is associated with high blood pressure and an increased risk for developing cardiovascular disease. The purpose of this study is to find out if the investigational drug angiotensin-(1-7) can improve cardiovascular health in people with obesity and high blood pressure.
- Multiple sclerosis (MS)
Effects of Ublituximab on Motor Functions in Multiple Sclerosis
Testing whether ublituximab changes walking and fall risk in people with relapsing multiple
📍 Georgia State University · Atlanta, GA · +1 more US site · Get directions →
The purpose of this study is to test if ublituximab changes walking functions and fall risk in people with relapsing multiple sclerosis (RMS). Twenty-five qualified people with RMS will undergo a 48-week ublituximab treatment.
- Obesity / overweightHeart / cardiovascular diseaseHigh cholesterol
Akkermansia Muciniphilia and Metabolic Side Effects of ADT
Testing how Akkermansia gut bacteria relate to body and blood lipid changes in people with obesity
📍 London Health Sciences Centre - Victoria Hospital · London, Ontario · Get directions →
The overriding objectives of this study are: 1. Primary outcomes: 1.
- Multiple sclerosis (MS)
Assessment of Synaptic Density in MS
Testing brain imaging to measure synapse density in progressive MS
📍 Brigham and Women's Hospital · Boston, MA · Get directions →
The investigators propose to use the novel SV2a-PET ligand, \[F-18\]SDM-8 to assess synaptic density in progressive multiple sclerosis (PMS) (including primary progressive multiple sclerosis (PPMS) and secondary progressive multiple sclerosis (SPMS)), given its improved imaging characteristics and potential for large scale applicability. The specific aims of the study are: Aim 1: To compare the cortical and subcortical grey matter synaptic density in PMS patients, patients with relapsing-remitting MS (RRMS), and healthy subjects, using a novel \[F-18\] labeled synaptic density PET ligand, \[F-18\]SDM8, also known as \[F-18\]SynvesT-1.
- Obesity / overweightHigh blood pressure
Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)
Studying how the nervous system controls blood pressure in obesity and high blood pressure
📍 University of Texas Southwestern Medical Center · Dallas, TX · Get directions →
The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function.