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6 studies
Recruiting now, in plain language. Every study is watched over by an independent ethics board.
- Anxiety
Self-Adjusted Nitrous Oxide: A Feasibility Study in the Setting of Vasectomy
Testing whether self-controlled nitrous oxide during vasectomy lowers pain and anxiety
📍 Beth Israel Deaconess Medical Center · Boston, MA · Get directions →
This study is being done to see if nitrous oxide during vasectomy decreases pain and anxiety, and also assess whether patients have better satisfaction when they control their own level of nitrous oxide during the procedure. If we find that patients experience less pain or anxiety with nitrous oxide, it could be suggested that self-adjusted nitrous oxide (SANO) may be a useful tool for improving experience of care during vasectomy.
- Anxiety
Pharmacogenetically-guided Escitalopram Treatment for Pediatric Anxiety: Aiming to Improve Safety and Efficacy (PrEcISE)
Testing whether genetic-guided dosing of a daily anxiety medicine helps kids
📍 University of Cincinnati, Department of Psychiatry & Behavioral Neuroscience · Cincinnati, OH · Get directions →
This double-blind, 12-week study will consist include132 anxious youth who are randomized (1:1) to standard or pharmacogenetically-guided escitalopram dosing. Block randomization (1:1) will be stratified by sex and metabolizer status.
- Anxiety
Adjunctive Treatment With L-methylfolate for Treatment-Resistant Generalized Anxiety Disorder: a Pilot Study
Testing whether adding L-methylfolate is safe and tolerated for hard-to-treat anxiety
📍 Kingston Health Sciences Centre · Kingston, Ontario · Get directions →
The goal of this feasibility study is to determine the tolerability and safety of add on treatment with L-methylfolate in patients with treatment-resistant generalized anxiety disorder (GAD). The primary objective is to monitor for side effects and other risks associated with the treatment.
- DepressionAnxiety
Processes and Circuitry Underlying Threat Sensitivity as a Treatment Target for Co-morbid Anxiety and Depression
Studying brain circuits for threat sensitivity in people with anxiety and depression
📍 Laureate Institute for Brain Research · Tulsa, OK · Get directions →
This mechanistic study uses an anti anxiety drug and brain imaging to study the threat processing system and associated brain circuits in people with depression, anxiety disorders and comorbid depression and anxiety disorders. In a double blind, placebo controlled crossover design, up to 65 individuals will be recruited who will have a diagnosis of major depressive disorder (MDD) and at least one anxiety disorder (AD) (AD-MDD group), up to 65 participants will have a diagnosis of MDD and no diagnosis of an AD and up to 65 participants will have no diagnosis of MDD and a diagnosis of at least one AD will be enrolled to participate in an two session study to obtain 150 completers (50 per group).
- Anxiety
Trial With the Treatment of Sertraline in Youth With Generalized, Separation and/or Social Anxiety Disorders.
Testing sertraline in young people with different anxiety disorders
📍 University of Cincinnati · Cincinnati, OH · Get directions →
A Multicenter, acute, randomized, double-blind, placebo-controlled, flexible-dose trial with the treatment of sertraline.
- DepressionAnxiety
Acute and Long-Term Antidepressant Treatment Success in Adolescents With Anxiety (AtLAS-A)
Testing antidepressant treatment for anxious teens with anxiety and depression
📍 University of Cincinnati · Cincinnati, OH · Get directions →
Acute, double-blind, adaptively randomized treatment with duloxetine or escitalopram, followed by open-label naturalistic follow-up.