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9 studies
Recruiting now, in plain language. Every study is watched over by an independent ethics board.
- Sickle cell disease💵 May compensate
Escalating Doses of VAS-101 in Subjects With Stable Sickle Cell Disease
Testing higher doses of VAS-101 in people with stable sickle cell disease
📍 National Institutes of Health Clinical Center · Bethesda, MD · Get directions →
Background: Sickle cell disease (SCD) is an inherited blood disorder. The disease affects the ability of red blood cells to carry oxygen.
- DepressionAnxiety💵 May compensate
Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy
Testing psilocybin-assisted therapy for depression and anxiety in people with advanced cancer
📍 MD Anderson Cancer Center · Houston, TX · Get directions →
To learn about the feasibility, safety, and effects of psilocybin-assisted psychotherapy on depression and/or anxiety in participants who are being treated for advanced cancer.
- Depression💵 May compensate
Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid Depression
Testing ketamine infusions plus brief counseling for veterans with low back pain and depression
📍 VA Ann Arbor Healthcare System, Ann Arbor, MI · Ann Arbor, MI · Get directions →
This is a pilot study to evaluate the feasibility, acceptability, and safety of ketamine infusions followed by a brief behavioral intervention in Veterans with chronic low back pain and depression.
- DepressionAnxiety💵 May compensate
TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer Survivors
Testing psilocybin-assisted therapy for depression and anxiety in cancer survivors
📍 The University of Texas M. D. Anderson Cancer Center · Houston, TX · Get directions →
This clinical research study is to learn about the feasibility, safety, and effects of psilocybin-assisted psychotherapy for cancer survivors with depression and/or anxiety.
- Crohn's / ulcerative colitis (IBD)💵 May compensate
Treatment of UC With Novel Therapeutics
Testing an oral medicine to treat mild ulcerative colitis over 12 weeks
📍 Brigham and Women's Hospital · Chestnut Hill, MA · Get directions →
This study is a clinical trial being done to investigate the efficacy of drug BRS201 as a treatment in patients with active mild ulcerative colitis. Participation in this study will take 12 weeks long and the study is structured as a crossover study in which participants will take the study drug for 4 weeks and a placebo drug for 4 weeks in a randomized order in the form of an oral medication.
- Crohn's / ulcerative colitis (IBD)💵 May compensate
Study of Novel Therapeutics for Acute Remedy of Colitis
Testing a new treatment in adults with acute ulcerative colitis
📍 Brigham and Women's Hospital · Chestnut Hill, MA · +1 more US site · Get directions →
This study is a clinical trial being done to investigate the efficacy of drug BRS201 as a treatment in patients with acute ulcerative colitis. Patients who qualify are adults who have not responded to treatments for their severe ulcerative colitis.
- Crohn's / ulcerative colitis (IBD)💵 May compensate
Open-label Single-arm Study to Assess the Efficacy of Mirikizumab in Patients With Inflammatory Strictures Due to CD
Testing whether mirikizumab is safe and works for people with Crohn’s strictures
📍 Digestive & Liver Center of Florida · Orlando, FL · +1 more US site · Get directions →
This is an open-label, single-arm, phase 4 study to assess the safety and efficacy of mirikizumab in approximately 60 participants with stricturing CD.
- DepressionAnxiety💵 May compensate
Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV
Testing whether pregnenolone pills affect brain function and depression in people with HIV
📍 Massachusetts General Hospital · Boston, MA · Get directions →
This study will determine the effects of pregnenolone on brain function, inflammation and depressive symptoms in people with HIV who have depression. Participants in this study will receive a pill of either pregnenolone or placebo, and can stay on their current antidepression medications.
- Depression💵 May compensate
Measuring Psychomotor Response to L-DOPA Challenge As a Biomarker for Outcomes in Late-Life Depression: a Pilot Feasibility Trial
Testing whether a brain response to L-DOPA can track outcomes in late-life depression
📍 St. Paul's Hospital · Vancouver, British Columbia · Get directions →
Background Adults over the age of 60 with symptoms of major depressive disorder are said to have late-life depression (LLD), a condition that usually decreases a person's quality of life and is associated with other risks like physical frailty and dementia. A common feature of more severe LLD is psychomotor slowing, where a person's ability to think and move are impaired.