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- Type 2 diabetes
📍 Central Research Associates - Flourish - PPDS · Birmingham, AL · +30 more US sites · Get directions →
This study is testing whether a new medication called CX11 works and is safe for participants with type 2 diabetes who have not reached good blood sugar control while taking a steady dose of metformin, with or without a steady dose of an SGLT2 inhibitor, for at least 90 days. The study is being done at multiple medical centers.
- Type 2 diabetes
HP-211 Safety and Proof of Concept Dose Ranging Study in Patients With Type 2 Diabetes
💵 May compensate📍 Alliance Clinical Canoga Park (Hope Clinical Research) · Canoga Park, CA · +24 more US sites · Get directions →
Blood sugar levels are controlled by insulin, a hormone made by cells in the pancreas. After a meal, carbohydrates are broken down into glucose which is absorbed from the intestine into the blood leading to a rise in glucose (blood sugar) which triggers the secretion of insulin.
- Type 2 diabetes
Glycemic and Weight Loss Effects of GLP-1R Agonist Therapy in Subjects With Spinal Cord Injury and Type 2 Diabetes
💵 May compensate📍 University Health - Texas Diabetic Institute · San Antonio, TX · +1 more US site · Get directions →
It is not known whether a new diabetes drug, semaglutide, is an effective treatment for type 2 diabetes for persons with spinal cord injury (SCI), a population at higher risk for this condition. Therefore, this study looks at the effect of semaglutide on glucose levels in the body and other information about type 2 diabetes and obesity.
- High blood pressure
Arterial Ablation for the Treatment of Type 2 Diabetes Mellitus and Its Comorbidities
💵 May compensate📍 Hospital Paitilla Clinicas y Hospitales · Panama City, · Get directions →
This study is assess the safety and performance of the Neurotronic Infusion catheter for treatment of patients with Type 2 Diabetes (T2DM) and hypertension.
- Obesity / overweightHigh blood pressure
Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease
💵 May compensate📍 Cleveland Clinic Main Campus · Cleveland, OH · Get directions →
Cirrhosis is a form of advanced liver disease that can lead to serious complications, especially when combined with severe obesity. Many patients with cirrhosis also develop a condition called clinically significant portal hypertension (CSPH), which is increased pressure in the veins of the liver.
- Type 2 diabetes
Patient Centered Multi-Agent Decision Support System (PCM-DSS) for Healthcare Providers
💵 May compensate📍 University of Virginia Center for Diabetes Technology · Charlottesville, VA · Get directions →
Decision Support System (Software) for multi antidiabetic drug therapy use in type 2 diabetes (T2D).
- Type 2 diabetesKidney disease
Mechanism of SGLT2 Inhibition in the Kidney
💵 May compensate📍 University of Michigan · Ann Arbor, MI · Get directions →
The goal of this open-label, non-randomized clinical trial is to determine what effects, if any, an FDA-approved drug class known as SGLT2 inhibitors (Canagliflozin or INVOKANA) has any protective effects on kidney function in Type 2 diabetes. We are looking for participants 18-80 years of age, who have had a clinical diagnosis of Type 2 diabetes for ≥ 3 years.
- Type 2 diabetesFatty liver disease (NASH/MASH)
Low-Dose Pioglitazone in Patients With NASH (AIM 2)
💵 May compensate📍 University of Florida · Gainesville, FL · Get directions →
To determine the safety and efficacy of low-dose pioglitazone (15 mg per day) on liver histology in in patients with T2DM with biopsy-proven nonalcoholic steatohepatitis (NASH).