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17 studies

Recruiting now, in plain language. Every study is watched over by an independent ethics board.

  • Multiple sclerosis (MS)

    📍 Washington University in St. Louis · St Louis, MO · Get directions →

    This study involves a Positron Emission Tomography (PET) scan using a new investigational radioactive tracer, \[18F\]-FZTA, to detect inflammation in the brain. The tracer will be tested in healthy younger adults and individuals with Multiple Sclerosis.

    ✓ Study care freeAges 18+Learn more →
  • Rheumatoid arthritis

    Targeted Remotely-delivered Anti-inflammatory Interventions With Exercise for Rheumatoid Arthritis

    Testing a remote exercise program (aerobic and strength) for people with rheumatoid arthritis

    💵 May compensate

    📍 Duke University · Durham, NC · Get directions →

    The primary objective of this study is to assess the feasibility of an intensive, remotely-delivered, combined aerobic and resistance training exercise program for patients with Rheumatoid Arthritis (RA) and to collect data to support power calculations for a larger research study.

    ✓ Study care freeAges 18+Learn more →
  • Dementia / Alzheimer's

    Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease

    Testing a brain stimulation approach to study memory and thinking in people with early

    💵 May compensate

    📍 Massachusetts General Hospital · Charlestown, MA · Get directions →

    The project is a placebo-controlled study that aims to use closed-loop transcranial alternating current stimulation (tACS) to study patients with symptoms of mild cognitive impairment which is likely due to Alzheimer's disease or another form of dementia (AD-MCI). Patients will undergo an EEG and complete some questionnaires and computer tasks during each study visit.

    ✓ Study care freeAges 50–80Learn more →
  • Dementia / Alzheimer's

    Study of LHP588 in Subjects With P. Gingivalis-Positive Alzheimer's Disease

    Testing an Alzheimer’s treatment in people with dementia and gum infection

    💵 May compensate

    📍 Banner Alzheimer's Institute · Phoenix, AZ · +38 more US sites · Get directions →

    This study is to test LHP588 in persons who have mild to moderate Alzheimer's disease (AD) who have shown progressive mental decline in the last year and who have P. gingivalis (Pg) infection.

    ✓ Study care freePhase 2Ages 55–80Learn more →
  • Anxiety

    Transcranial Alternating Current Stimulation (tACS) for the Treatment of Anxiety in Veterans: An Open-Label Pilot Study

    Testing a wearable brain stimulation device to treat anxiety in veterans

    💵 May compensate

    📍 Birmingham VA · Birmingham, AL · Get directions →

    Transcranial alternating current stimulation (tACS) in a wearable brain stimulation device that delivers a low intensity, pulsed, alternating current via scalp electrodes. Prior sham-controlled clinical trials have shown the therapeutic effects and safety of tACS for the treatment of anxiety and depression.

    ✓ Study care freeAges 19–70Learn more →
  • Anxiety

    Implementing Team-Based Treatment for Pediatric Anxiety in Community Mental Health Settings

    Testing different ways to deliver talk therapy skills for kids with anxiety

    💵 May compensate

    📍 Bradley Hospital · East Providence, RI · Get directions →

    The purpose of this study is to test how the delivery of Cognitive Behavioral Therapy (CBT) for pediatric anxiety and OCD via different methods might increase its availability and effectiveness. CBT involves teaching the patient skills to enable them to gradually come into contact with feared situations.

    ✓ Study care freeAges 5–18Learn more →
  • Dementia / Alzheimer's

    Investigation of Inflammation in Alzheimer's Disease and Related Dementias (ADRD) Using [11C]-CS1P1

    Testing a brain scan tracer to measure inflammation in dementia

    💵 May compensate

    📍 Washington University School of Medicine · St Louis, MO · Get directions →

    This study involves a brain positron emission tomography (PET) scan with a new, investigational radioactive tracer called \[11C\]-CS1P1 to identify inflammation in the brain by testing with healthy older adults and with cognitively impaired older adults.

    ✓ Study care freeAges 50+Learn more →
  • Anxiety

    Non-invasive Cranial Electrical Stimulation for Mealtime Anxiety in Adults With Eating Disorders

    Testing a non-invasive brain stimulation device to help treat mealtime anxiety in adults with eating

    💵 May compensate

    📍 Rogers Behavioral Health · Oconomowoc, WI · Get directions →

    The study is to evaluate the feasibility of using a non-invasive brain stimulation device in a sample of inpatients with eating disorders (ED). The study will help researchers evaluate whether their device protocol is practical for eating disorder inpatients as a way to manage eating disorder and anxiety symptoms.

    ✓ Study care freeAges 18–30Learn more →
  • Dementia / Alzheimer's

    Intervention for Communication Quality of Life in Primary Progressive Aphasia

    Testing an online speech and language program to improve communication and quality of life for

    💵 May compensate

    📍 University of Texas · Austin, TX · Get directions →

    The goal of this clinical trial is to learn whether a personalized, multi-component, virtual speech language treatment program can improve communication and quality of life for adults with primary progressive aphasia (PPA) and their primary communication partners. The study will enroll participants who speak English and/or Spanish.

    ✓ Study care freeAges 40+Learn more →
  • DepressionAnxiety

    Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy

    Testing psilocybin-assisted therapy for depression and anxiety in people with advanced cancer

    💵 May compensate

    📍 MD Anderson Cancer Center · Houston, TX · Get directions →

    To learn about the feasibility, safety, and effects of psilocybin-assisted psychotherapy on depression and/or anxiety in participants who are being treated for advanced cancer.

    ✓ Study care freePhase 2Ages 25+Learn more →
  • Parkinson's disease

    SAD Study in Patients With Parkinson's Disease and Motor Fluctuations

    Testing a single dose of SER-252 in people with Parkinson’s disease

    💵 May compensate

    📍 Rocky Mountain Clinical Research · Englewood, CO · +3 more US sites · Get directions →

    This is a randomized, placebo-controlled, single ascending dose (SAD) study of SER-252 in participants with Parkinson's Disease (PD) and motor fluctuations.

    ✓ Study care freePhase 1Ages 40–80Learn more →
  • DepressionAnxiety

    TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer Survivors

    Testing psilocybin-assisted therapy for depression and anxiety in cancer survivors

    💵 May compensate

    📍 The University of Texas M. D. Anderson Cancer Center · Houston, TX · Get directions →

    This clinical research study is to learn about the feasibility, safety, and effects of psilocybin-assisted psychotherapy for cancer survivors with depression and/or anxiety.

    ✓ Study care freePhase 2Ages 18+Learn more →
  • Multiple sclerosis (MS)

    Prospective Evaluation of Sequencing From antiCD-20 Therapies to Ozanimod

    Testing whether ozanimod is safe and works as a step-down treatment for stable multiple sclerosis

    💵 May compensate

    📍 University of Colorado Anschutz Medical Campus · Aurora, CO · +2 more US sites · Get directions →

    A multi-center pilot study to evaluate safety and efficacy of ozanimod as de-escalation therapy in clinically stable MS patients previously treated with anti-CD20 therapy.

    ✓ Study care freePhase 4Ages 18+Learn more →
  • DepressionAnxiety

    Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV

    Testing whether pregnenolone pills affect brain function and depression in people with HIV

    💵 May compensate

    📍 Massachusetts General Hospital · Boston, MA · Get directions →

    This study will determine the effects of pregnenolone on brain function, inflammation and depressive symptoms in people with HIV who have depression. Participants in this study will receive a pill of either pregnenolone or placebo, and can stay on their current antidepression medications.

    ✓ Study care freePhase 2Ages 18–85Learn more →
  • Parkinson's disease

    Blood Pressure Effects on Cognition and Brain Blood Flow in PD

    Testing how blood pressure in Parkinson’s affects thinking and brain blood flow

    💵 May compensate

    📍 University of California San Diego · San Diego, CA · Get directions →

    Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide. Besides causing symptoms that impair movement, PD also causes non-motor symptoms, such as problems thinking and orthostatic hypotension (OH), i.e., low blood pressure (BP) when standing.

    ✓ Study care freeAges 50+Learn more →
  • Migraine / chronic headache

    Real-world Prospective Study on the Use of Anti-CGRP Drugs in Migraine

    Studying real-world results of migraine preventive medicines targeting CGRP

    💵 May compensate

    📍 University of Miami, Miller School of Medicine · Miami, FL · Get directions →

    The goal of this observational study is to evaluate clinical differences in patients who received preventive treatment with medication targeting calcitonin gene-related peptide (CGRP) or its receptor: monoclonal antibodies (erenumab, galcanezumab, fremanezumab, eptinezumab) or gepants (rimegepant, atogepant) during a 2-year period observation phase.

    ✓ Study care freeAges 18+Learn more →
  • Rheumatoid arthritis

    EMPHASYS Cup Positioning in THA With Non-Invasive Navigation (Velys Hip Navigation (VHN))

    Studying how well a hip replacement cup is positioned in people with rheumatoid arthritis using

    💵 May compensate

    📍 UC Davis Health System · Sacramento, CA · +4 more US sites · Get directions →

    The purpose of this research is to gather clinical and radiographic (X-ray) information about EMPHASYS™ acetabular shell (also called a hip 'cup') placement in total hip replacement surgery using a non-invasive surgical navigation system called VELYS™ hip navigation system with CUPTIMIZE™ Advanced Hip-Spine Analysis software. Data collected in this study will be compared with data collected from implantations using different cup positioning instrumentation and techniques to assess performance.

    ✓ Study care freeAges 21+Learn more →