Obesity / overweight

The Effects of Strength Training on Muscle Mass and Mental Health in Adults Taking Obesity Medication

Recruiting · Pittsburgh, Pennsylvania

✓ Study treatment at no cost

Always free

Study care at no cost to you

For your time and travel

Many studies pay you back

Most need no insurance or papers

Legal status usually isn't required; we'll tell you each study's requirements

Interpreters available

Ask for your language

Your choice

Voluntary — you can stop anytime

What is this study?

It is , overseen by an independent and licensed medical staff.

Read the full clinical description

The purpose of this study is to examine the effects of resistance exercise, such as weightlifting, on retention of muscle mass and mental health in individuals taking GLP-1 RAs (an obesity medication). Resistance exercise is focused on increasing the strength of participants' muscles, such as how much participant can lift. •The duration of this study is 3 months. This includes: * Orientation session to explain study protocol, exercise program, and complete questionnaire about participants' medical history and lifestyle. * Two health assessments at baseline and at 3 months. These assessments include body composition, resting blood pressure, cardiovascular function, and muscular strength. Both the resistance exercise group and the control group will complete assessments at baseline and again at 3 months. After the 3-month period, individuals in the control group may choose to participate in the exercise training and complete the optional 6-month assessments. * Personalized resistance exercise sessions for 60 minutes per session, twice per week, for 3 months.

Who this study is looking for

In plain language, from the study's own rules. The study team confirms the full details with you — this isn't a final yes or no.

✅ You may be able to join if…

•Adults who are starting an obesity medicine called a GLP-1 RA and agree to wait to start the drug until after the baseline check
•Age 18 or older
•Non-smokers
•Have obesity based on BMI, plus at least one weight-related health problem (either hypertension or sleep apnea reported by the participant)
•Can safely take part in the required exercise program

🚫 You may not be able to join if…

•Have a serious heart problem such as unstable heart disease or heart failure, poorly controlled irregular heartbeats, severe valve narrowing, or recent heart inflammation
•Have had cancer that needs treatment in the past 5 years
•Have thyroid disease (hypothyroidism or hyperthyroidism)
•Have a history of medullary thyroid carcinoma (MTC) or MEN2 (multiple endocrine neoplasia type 2)
•Have diabetes (type 1 or type 2) or uncontrolled high blood pressure (systolic ≥160 mm Hg or diastolic ≥100 mm Hg)

Are you a good fit?

Simplified highlights. The study team always confirms the full details with you.

✓Adults roughly 18 and older
✓A BMI around 27 or higher
✓Have Obesity / overweight or High blood pressure

!Some conditions may not be a fit: Heart / cardiovascular disease
!Not for people who are pregnant or breastfeeding
!May require a break from current GLP-1 medications

What to expect, step by step

1
Usually a few weeks
The study team checks whether the study is a good fit for you, with a visit and sometimes lab tests. You can ask any questions before deciding.
2
Treatment
If you join and choose to continue, you receive the study treatment and are watched closely by medical staff.
3
Follow-up
After treatment, the team checks on your health and confirms the visit schedule with you. You can leave the study at any point.

Has this treatment been tested before?

The study team can share what safety testing has been done so far.

What you need to know before you apply

What is this study testing?+

Is it safe? Who makes sure of that?+

This is a research study. Every study is reviewed and monitored by an independent ethics board (called an IRB) whose job is to protect participants, and care is overseen by licensed medical staff. You'll be told the known risks before you agree to anything, and you can stop at any time.

Will I get a placebo instead of the real treatment?+

Some studies compare a treatment against a placebo (an inactive version), and some don't. If this one does, the study team will explain your chances of receiving the active treatment before you decide. Nothing is hidden from you.

I take a GLP-1 medication (like Ozempic or Wegovy). Can I still join?+

Maybe. This study may ask you to pause certain weight or diabetes medications for a period of time (a 'washout') before joining, or it may be looking for people not currently on them. The coordinator will review your medications with you — don't stop any medication on your own.

Does it cost anything? Will I be paid?+

The study treatment and study-related visits are provided at no cost to you. Some studies also pay for your time; the coordinator can tell you if this one does. You should never be asked to pay to take part.

Do I need insurance? Will anyone ask about my immigration status?+

No. You do not need health insurance to take part in a research study, and you will not be asked about your immigration status to join. Taking part is about whether you're a medical fit for the study.

What if English isn't my first language?+

You have the right to understand everything before you agree. Study sites can often provide materials or an interpreter in your language — you can ask the coordinator for one.

Is my information private?+

Yes. Your health information is only shared with the study sites you choose to be contacted by, and only to help match and enroll you. It is never sold, and you can ask us to delete it at any time.

Some requirements (like specific lab values or timing) are confirmed directly by the study team, not by us.

Source: ClinicalTrials.gov · NCT07652333 · Locations: Pennsylvania