Evaluating the Pharmacokinetics and Safety of Miricorilant
Recruiting · San Antonio, Texas
Always free
Study care at no cost to you
For your time and travel
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Most need no insurance or papers
Legal status usually isn't required; we'll tell you each study's requirements
Interpreters available
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Your choice
Voluntary — you can stop anytime
What is this study?
A Phase 1b, Open-Label Study Evaluating the Pharmacokinetics and Safety of Miricorilant in Adult Patients With Presumed Metabolic Dysfunction-Associated Steatohepatitis (MASH)
It is , overseen by an independent and licensed medical staff.
Read the full clinical description
A Phase 1b, Open-Label Study Evaluating the Pharmacokinetics and Safety of Miricorilant in Adult Patients With Presumed Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Who this study is looking for
In plain language, from the study's own rules. The study team confirms the full details with you — this isn't a final yes or no.
✅ You may be able to join if…
- •Adults with presumed MASH confirmed by FibroScan or a biopsy (within 12 months).
- •Liver results that match one of the listed fibrosis and activity score combinations.
- •Blood test liver enzyme AST above specific limits (unless you have an eligible biopsy within 12 months).
- •You also have type 2 diabetes OR at least 2 metabolic syndrome components (from the list in the study).
🚫 You may not be able to join if…
- •Pregnant, planning pregnancy, or breastfeeding (women).
- •BMI is too low (< 18) or too high (> 45).
- •Heavy alcohol use in the past year (more than 20 g/day for women or 30 g/day for men) or an AUDIT score of 8 or higher.
- •You have had a liver transplant (or plan to during the study).
- •You have type 1 diabetes, poorly controlled type 2 diabetes (HbA1c 9.5% or higher), any other chronic liver disease, a history/evidence of cirrhosis, or signs of liver “decompensation” (worsening liver function).
Are you a good fit?
Simplified highlights. The study team always confirms the full details with you.
- ✓Adults with presumed MASH/steatohepatitis (MASH) based on FibroScan or recent biopsy
- ✓Evidence of metabolic risk (like type 2 diabetes or multiple metabolic syndrome factors)
- ✓BMI between 18 and 45 kg/m²
- ✓Not pregnant or breastfeeding (and not planning pregnancy)
- ✓Type 1 diabetes or very poorly controlled diabetes would not qualify
- ✓No history/evidence of cirrhosis, hepatic decompensation, or significant alcohol use
- !Not for people who are pregnant or breastfeeding
How this study is designed
The real details, in plain words. Tap the underlined words to learn what they mean.
- ✓Everyone in this study receives an active treatment — there is no placebo group.
What to expect, step by step
· This study lasts about 1 weeks- 1
Usually a few weeks
The study team checks whether the study is a good fit for you, with a visit and sometimes lab tests. You can ask any questions before deciding.
- 2
Treatment
About 1 weeksIf you join and choose to continue, you receive the study treatment and are watched closely by medical staff.
- 3
Follow-up
After treatment, the team checks on your health and confirms the visit schedule with you. You can leave the study at any point.
What's being tested
- Drug: Miricorilant
Has this treatment been tested before?
This is an early-stage study. The treatment has gone through laboratory and preliminary testing before being studied in people here.
Who's running this study?
Sponsor
Corcept Therapeutics
Overseen by Aprille Espinueva, PharmD
Every study is also reviewed by an independent that protects participants.
What you need to know before you apply
What is this study testing?+
A Phase 1b, Open-Label Study Evaluating the Pharmacokinetics and Safety of Miricorilant in Adult Patients With Presumed Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Is it safe? Who makes sure of that?+
This is an early study (Phase 1), focused mostly on safety. Every study is reviewed and monitored by an independent ethics board (called an IRB) whose job is to protect participants, and care is overseen by licensed medical staff. You'll be told the known risks before you agree to anything, and you can stop at any time.
Will I get a placebo instead of the real treatment?+
Some studies compare a treatment against a placebo (an inactive version), and some don't. If this one does, the study team will explain your chances of receiving the active treatment before you decide. Nothing is hidden from you.
Do I have to stop taking my current medications?+
It depends on the study. Some let you stay on your current medications and some ask you to adjust them. Never stop a medication on your own — the study team will review everything with you first.
Does it cost anything? Will I be paid?+
The study treatment and study-related visits are provided at no cost to you. This study may also compensate you for your time and travel — the team will tell you the amount before you join. You should never be asked to pay to take part.
Do I need insurance? Will anyone ask about my immigration status?+
No. You do not need health insurance to take part in a research study, and you will not be asked about your immigration status to join. Taking part is about whether you're a medical fit for the study.
What if English isn't my first language?+
You have the right to understand everything before you agree. Study sites can often provide materials or an interpreter in your language — you can ask the coordinator for one.
Is my information private?+
Yes. Your health information is only shared with the study sites you choose to be contacted by, and only to help match and enroll you. It is never sold, and you can ask us to delete it at any time.
Some requirements (like specific lab values or timing) are confirmed directly by the study team, not by us.
Source: ClinicalTrials.gov · NCT07553663 · Locations: Texas