A Study of Efficacy and Safety of Depemokimab Compared With Placebo in Adults and Adolescents With at Risk Type 2 Asthma
Recruiting · 8 sites across 4 states
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Study care at no cost to you
For your time and travel
Many studies pay you back
Most need no insurance or papers
Legal status usually isn't required; we'll tell you each study's requirements
Interpreters available
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Your choice
Voluntary — you can stop anytime
What is this study?
The aim of this study is to evaluate the efficacy of depemokimab administered as an adjunctive therapy, in participants with Type 2 asthma at risk of exacerbations compared to the guideline recommended standard of care (SoC).
It is , overseen by an independent and licensed medical staff.
Read the full clinical description
The aim of this study is to evaluate the efficacy of depemokimab administered as an adjunctive therapy, in participants with Type 2 asthma at risk of exacerbations compared to the guideline recommended standard of care (SoC).
Who this study is looking for
In plain language, from the study's own rules. The study team confirms the full details with you — this isn't a final yes or no.
✅ You may be able to join if…
- •People with asthma that a doctor diagnosed for at least 2 years (meeting major asthma guideline standards).
- •People age 12 years and older (or 18+ in places where only adults can be enrolled by local rules).
- •People who had at least 2 asthma flare-ups in the last 3 years, with at least 1 in the year before screening.
- •People who are already taking low or medium dose inhaled steroid plus a long-acting asthma inhaler, and their dose has been stable for 3 months.
- •People whose asthma is “Type 2 high disease at risk” based on blood eosinophils and/or nitric oxide and/or nasal polyps (as defined in the study).
🚫 You may not be able to join if…
- •People who had 3 or more asthma flare-ups in the last year before Visit 1.
- •People taking maintenance oral steroids (OCS) or high-dose inhaled steroid plus LABA for asthma.
- •People whose asthma has lasted more than 20 years.
- •People with other important lung diseases besides asthma (for example bronchiectasis, lung scarring/fibrosis, lung cancer history, emphysema, chronic bronchitis/COPD).
- •People who are pregnant or breastfeeding, or who have had a suspected/alarming lack of ability to follow controller medicine instructions and study directions.
Are you a good fit?
Simplified highlights. The study team always confirms the full details with you.
- ✓Adults roughly 12–any age
- ✓Have Asthma
- !Some conditions may not be a fit: COPD (chronic lung disease)
- !Not for people who are pregnant or breastfeeding
What to expect, step by step
- 1
Usually a few weeks
The study team checks whether the study is a good fit for you, with a visit and sometimes lab tests. You can ask any questions before deciding.
- 2
Treatment
If you join and choose to continue, you receive the study treatment and are watched closely by medical staff.
- 3
Follow-up
After treatment, the team checks on your health and confirms the visit schedule with you. You can leave the study at any point.
Has this treatment been tested before?
Yes. This treatment has already been through earlier human studies for safety before reaching this stage.
What you need to know before you apply
What is this study testing?+
The aim of this study is to evaluate the efficacy of depemokimab administered as an adjunctive therapy, in participants with Type 2 asthma at risk of exacerbations compared to the guideline recommended standard of care (SoC).
Is it safe? Who makes sure of that?+
This is a late-stage study (Phase 3), testing how well the treatment works in more people. Every study is reviewed and monitored by an independent ethics board (called an IRB) whose job is to protect participants, and care is overseen by licensed medical staff. You'll be told the known risks before you agree to anything, and you can stop at any time.
Will I get a placebo instead of the real treatment?+
Some studies compare a treatment against a placebo (an inactive version), and some don't. If this one does, the study team will explain your chances of receiving the active treatment before you decide. Nothing is hidden from you.
Do I have to stop taking my current medications?+
It depends on the study. Some let you stay on your current medications and some ask you to adjust them. Never stop a medication on your own — the study team will review everything with you first.
Does it cost anything? Will I be paid?+
The study treatment and study-related visits are provided at no cost to you. Some studies also pay for your time; the coordinator can tell you if this one does. You should never be asked to pay to take part.
Do I need insurance? Will anyone ask about my immigration status?+
No. You do not need health insurance to take part in a research study, and you will not be asked about your immigration status to join. Taking part is about whether you're a medical fit for the study.
What if English isn't my first language?+
You have the right to understand everything before you agree. Study sites can often provide materials or an interpreter in your language — you can ask the coordinator for one.
Is my information private?+
Yes. Your health information is only shared with the study sites you choose to be contacted by, and only to help match and enroll you. It is never sold, and you can ask us to delete it at any time.
Some requirements (like specific lab values or timing) are confirmed directly by the study team, not by us.
Source: ClinicalTrials.gov · NCT07456033 · Locations: California · Florida · Oklahoma · South Dakota