Proof-of-Concept Study Evaluating Total Body Weight, Physical Function & Safety of Enobosarm in Patients Treated With GLP-1 Receptor Agonist, for Weight Loss
Recruiting · 14 sites across 10 states
Always free
Study care at no cost to you
For your time and travel
Many studies pay you back
Most need no insurance or papers
Legal status usually isn't required; we'll tell you each study's requirements
Interpreters available
Ask for your language
Your choice
Voluntary — you can stop anytime
What is this study?
The primary objective of this study is to assess the effect of enobosarm on total body weight
It is , overseen by an independent and licensed medical staff.
Read the full clinical description
The primary objective of this study is to assess the effect of enobosarm on total body weight
Who this study is looking for
In plain language, from the study's own rules. The study team confirms the full details with you — this isn't a final yes or no.
✅ You may be able to join if…
- •People who are 65 years or older at screening
- •People with BMI 35 or higher
- •People who can take and continue semaglutide for weight reduction for up to 476 days
- •People willing to follow the study rules through the end of the study
- •People who can swallow oral medicines and complete the stair-climb test
🚫 You may not be able to join if…
- •Anyone allergic to enobosarm or to a GLP-1 receptor agonist
- •People with very low kidney function (eGFR < 30 mL/min/1.73 m2)
- •People with certain heart rhythm findings (QTcF too high or an ECG judged high-risk)
- •People with significant liver problems, or liver blood tests that are too high (ALT/AST > 3x upper limit of normal)
- •People with diabetes that needs current antidiabetic drugs, or with HbA1c ≥6.5%
Are you a good fit?
Simplified highlights. The study team always confirms the full details with you.
- ✓Adults roughly 65–100
- ✓A BMI around 35 or higher
- ✓Have Obesity / overweight
- !Some conditions may not be a fit: Fatty liver disease (NASH/MASH), High blood pressure, Kidney disease, Depression
- !May require a break from current GLP-1 medications
What to expect, step by step
- 1
Usually a few weeks
The study team checks whether the study is a good fit for you, with a visit and sometimes lab tests. You can ask any questions before deciding.
- 2
Treatment
If you join and choose to continue, you receive the study treatment and are watched closely by medical staff.
- 3
Follow-up
After treatment, the team checks on your health and confirms the visit schedule with you. You can leave the study at any point.
Has this treatment been tested before?
Yes. This treatment has already been through earlier human studies for safety before reaching this stage.
What you need to know before you apply
What is this study testing?+
The primary objective of this study is to assess the effect of enobosarm on total body weight
Is it safe? Who makes sure of that?+
This is a mid-stage study (Phase 2), looking at safety and whether the treatment works. Every study is reviewed and monitored by an independent ethics board (called an IRB) whose job is to protect participants, and care is overseen by licensed medical staff. You'll be told the known risks before you agree to anything, and you can stop at any time.
Will I get a placebo instead of the real treatment?+
Some studies compare a treatment against a placebo (an inactive version), and some don't. If this one does, the study team will explain your chances of receiving the active treatment before you decide. Nothing is hidden from you.
I take a GLP-1 medication (like Ozempic or Wegovy). Can I still join?+
Maybe. This study may ask you to pause certain weight or diabetes medications for a period of time (a 'washout') before joining, or it may be looking for people not currently on them. The coordinator will review your medications with you — don't stop any medication on your own.
Does it cost anything? Will I be paid?+
The study treatment and study-related visits are provided at no cost to you. Some studies also pay for your time; the coordinator can tell you if this one does. You should never be asked to pay to take part.
Do I need insurance? Will anyone ask about my immigration status?+
No. You do not need health insurance to take part in a research study, and you will not be asked about your immigration status to join. Taking part is about whether you're a medical fit for the study.
What if English isn't my first language?+
You have the right to understand everything before you agree. Study sites can often provide materials or an interpreter in your language — you can ask the coordinator for one.
Is my information private?+
Yes. Your health information is only shared with the study sites you choose to be contacted by, and only to help match and enroll you. It is never sold, and you can ask us to delete it at any time.
Some requirements (like specific lab values or timing) are confirmed directly by the study team, not by us.
Source: ClinicalTrials.gov · NCT07446998 · Locations: Arizona · Florida · Georgia · Louisiana · Maryland · Mississippi · New York · North Carolina · Texas · Washington