A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)
Recruiting · 40 sites across 13 states
Always free
Study care at no cost to you
For your time and travel
Many studies pay you back
Most need no insurance or papers
Legal status usually isn't required; we'll tell you each study's requirements
Interpreters available
Ask for your language
Your choice
Voluntary — you can stop anytime
What is this study?
The purpose of this pediatric, chronic weight management, Phase 3 Master Protocol (PWMP) is to create a framework to evaluate the safety and efficacy of pharmacologic agents for the treatment of obesity or overweight in pediatric participants.
It is , overseen by an independent and licensed medical staff.
Read the full clinical description
The purpose of this pediatric, chronic weight management, Phase 3 Master Protocol (PWMP) is to create a framework to evaluate the safety and efficacy of pharmacologic agents for the treatment of obesity or overweight in pediatric participants.
Who this study is looking for
In plain language, from the study's own rules. The study team confirms the full details with you — this isn't a final yes or no.
✅ You may be able to join if…
- •Ages between 12 and under 18 years old.
- •Have a history of at least 1 unsuccessful effort to lose enough weight after a structured lifestyle program (diet and exercise counseling for at least 3 months) before screening.
- •Have obesity: BMI at or above the 95th percentile for age and sex (using CDC-NCHS growth charts). OR have overweight: BMI at or above the 85th percentile but below the 95th percentile, PLUS at least 1 weight-related health problem.
- •If overweight, have at least 1 weight-related comorbidity listed: hypertension, type 2 diabetes, prediabetes, dyslipidemia, obstructive sleep apnea, or metabolic dysfunction-associated steatohepatitis (MASH) / metabolic dysfunction-associated steatotic liver disease (MASLD).
🚫 You may not be able to join if…
- •Plan to have, or already had, a weight-loss procedure during the study (examples include gastric bypass or sleeve gastrectomy).
- •Have obesity caused by another medical condition (secondary cause) or a history of sudden (abrupt) weight gain that suggests a secondary cause (examples given include hypothalamic, monogenetic, syndromic, or endocrine causes).
- •Had a body weight decrease of more than 5 kg (11 lbs) in the 90 days before screening (reported by participant or parent/guardian where applicable), regardless of medical records.
- •Have type 1 diabetes or a history of ketoacidosis or a hyperosmolar state.
- •Have HbA1c greater than 9.0% (75 mmol/mol) at screening, or have a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia Syndrome Type 2.
Are you a good fit?
Simplified highlights. The study team always confirms the full details with you.
- ✓Adults roughly 6–17
- ✓Have Obesity / overweight or Type 2 diabetes or Fatty liver disease (NASH/MASH) or High blood pressure or High cholesterol
What to expect, step by step
- 1
Usually a few weeks
The study team checks whether the study is a good fit for you, with a visit and sometimes lab tests. You can ask any questions before deciding.
- 2
Treatment
If you join and choose to continue, you receive the study treatment and are watched closely by medical staff.
- 3
Follow-up
After treatment, the team checks on your health and confirms the visit schedule with you. You can leave the study at any point.
Has this treatment been tested before?
Yes. This treatment has already been through earlier human studies for safety before reaching this stage.
What you need to know before you apply
What is this study testing?+
The purpose of this pediatric, chronic weight management, Phase 3 Master Protocol (PWMP) is to create a framework to evaluate the safety and efficacy of pharmacologic agents for the treatment of obesity or overweight in pediatric participants.
Is it safe? Who makes sure of that?+
This is a late-stage study (Phase 3), testing how well the treatment works in more people. Every study is reviewed and monitored by an independent ethics board (called an IRB) whose job is to protect participants, and care is overseen by licensed medical staff. You'll be told the known risks before you agree to anything, and you can stop at any time.
Will I get a placebo instead of the real treatment?+
Some studies compare a treatment against a placebo (an inactive version), and some don't. If this one does, the study team will explain your chances of receiving the active treatment before you decide. Nothing is hidden from you.
Do I have to stop taking my current medications?+
It depends on the study. Some let you stay on your current medications and some ask you to adjust them. Never stop a medication on your own — the study team will review everything with you first.
Does it cost anything? Will I be paid?+
The study treatment and study-related visits are provided at no cost to you. Some studies also pay for your time; the coordinator can tell you if this one does. You should never be asked to pay to take part.
Do I need insurance? Will anyone ask about my immigration status?+
No. You do not need health insurance to take part in a research study, and you will not be asked about your immigration status to join. Taking part is about whether you're a medical fit for the study.
What if English isn't my first language?+
You have the right to understand everything before you agree. Study sites can often provide materials or an interpreter in your language — you can ask the coordinator for one.
Is my information private?+
Yes. Your health information is only shared with the study sites you choose to be contacted by, and only to help match and enroll you. It is never sold, and you can ask us to delete it at any time.
Some requirements (like specific lab values or timing) are confirmed directly by the study team, not by us.
Source: ClinicalTrials.gov · NCT06672549 · Locations: California · Connecticut · Georgia · Illinois · Louisiana · Mississippi · Missouri · Nebraska · North Carolina · Pennsylvania · Tennessee · Texas · Utah