Extracellular Vesicles, Insulin Action, and Exercise
Recruiting · New Brunswick, New Jersey
Always free
Study care at no cost to you
For your time and travel
Many studies pay you back
Most need no insurance or papers
Legal status usually isn't required; we'll tell you each study's requirements
Interpreters available
Ask for your language
Your choice
Voluntary — you can stop anytime
What is this study?
Extracellular vesicles (EVs) play a role in obesity-induced insulin resistance and likely impact the development of cardiovascular disease. However, little is known on how EVs affect vascular insulin action in people.
It is , overseen by an independent and licensed medical staff.
Read the full clinical description
Extracellular vesicles (EVs) play a role in obesity-induced insulin resistance and likely impact the development of cardiovascular disease. However, little is known on how EVs affect vascular insulin action in people. The purpose of this study is to understand how EVs play a role in type 2 diabetes related cardiovascular disease. This research will also study if exercise can change how EVs impact blood flow and metabolic health. This study will contribute to designing precision medicine to treat/prevent cardiovascular disease in type 2 diabetes.
Who this study is looking for
In plain language, from the study's own rules. The study team confirms the full details with you — this isn't a final yes or no.
✅ You may be able to join if…
- •You are male or female and 30 to 80 years old.
- •Your diabetes status fits the study blood-sugar rules: either HbA1c < 5.7% and fasting glucose < 100 mg/dl (no diabetes, NGT), or type 2 diabetes with HbA1c ≥ 6.5% and fasting glucose ≥ 126 mg/dl.
- •You take diabetes medicines that include metformin, GLP-1 agonists (pills or shots), TZDs, DPP-IV inhibitors, acarbose, or SGLT-2 inhibitors for at least 6 years.
- •Your body mass index (BMI) is 20 to 24.99 or 25.0 to 45 kg/m2.
- •You are not diagnosed with type 1 diabetes and you are not exercising more than 150 minutes per week.
🚫 You may not be able to join if…
- •You have morbid obesity (BMI > 45 kg/m2) or you are underweight (BMI ≤ 18 kg/m2).
- •You are intolerant to insulin, or you have evidence of type 1 diabetes or need insulin therapy.
- •Your weight has not been stable (more than 2 kg change in the last 6 months).
- •You were already very active in the last 6 months (at least 150 minutes/week of moderate/high intensity exercise).
- •You have certain safety issues such as recent smoking (quit within 2 years), major abnormal labs (like very high HbA1c ≥ 10.0%, high triglycerides ≥ 400 mg/dl, high cholesterol ≥ 260 mg/dl), kidney dysfunction, uncontrolled high blood pressure (≥160/100), abnormal liver tests, anemia, possible infections, or you are pregnant or nursing.
Are you a good fit?
Simplified highlights. The study team always confirms the full details with you.
- ✓Adults roughly 30–80
- ✓Have Obesity / overweight
- !Some conditions may not be a fit: Kidney disease
- !Not for people who are pregnant or breastfeeding
- !May require a break from current GLP-1 medications
What to expect, step by step
- 1
Usually a few weeks
The study team checks whether the study is a good fit for you, with a visit and sometimes lab tests. You can ask any questions before deciding.
- 2
Treatment
If you join and choose to continue, you receive the study treatment and are watched closely by medical staff.
- 3
Follow-up
After treatment, the team checks on your health and confirms the visit schedule with you. You can leave the study at any point.
Has this treatment been tested before?
The study team can share what safety testing has been done so far.
What you need to know before you apply
What is this study testing?+
Extracellular vesicles (EVs) play a role in obesity-induced insulin resistance and likely impact the development of cardiovascular disease. However, little is known on how EVs affect vascular insulin action in people.
Is it safe? Who makes sure of that?+
This is a research study. Every study is reviewed and monitored by an independent ethics board (called an IRB) whose job is to protect participants, and care is overseen by licensed medical staff. You'll be told the known risks before you agree to anything, and you can stop at any time.
Will I get a placebo instead of the real treatment?+
Some studies compare a treatment against a placebo (an inactive version), and some don't. If this one does, the study team will explain your chances of receiving the active treatment before you decide. Nothing is hidden from you.
I take a GLP-1 medication (like Ozempic or Wegovy). Can I still join?+
Maybe. This study may ask you to pause certain weight or diabetes medications for a period of time (a 'washout') before joining, or it may be looking for people not currently on them. The coordinator will review your medications with you — don't stop any medication on your own.
Does it cost anything? Will I be paid?+
Study-related care is provided at no cost to you. Some studies also pay for your time; the coordinator can tell you if this one does. You should never be asked to pay to take part.
Do I need insurance? Will anyone ask about my immigration status?+
No. You do not need health insurance to take part in a research study, and you will not be asked about your immigration status to join. Taking part is about whether you're a medical fit for the study.
What if English isn't my first language?+
You have the right to understand everything before you agree. Study sites can often provide materials or an interpreter in your language — you can ask the coordinator for one.
Is my information private?+
Yes. Your health information is only shared with the study sites you choose to be contacted by, and only to help match and enroll you. It is never sold, and you can ask us to delete it at any time.
Some requirements (like specific lab values or timing) are confirmed directly by the study team, not by us.
Source: ClinicalTrials.gov · NCT06546085 · Locations: New Jersey