A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Inadequately Controlled Moderate to Severe Asthma
Recruiting · 40 sites across 11 states
Always free
Study care at no cost to you
For your time and travel
Many studies pay you back
Most need no insurance or papers
Legal status usually isn't required; we'll tell you each study's requirements
Interpreters available
Ask for your language
Your choice
Voluntary — you can stop anytime
What is this study?
This study tests how well different doses of povorcitinib work and whether it is safe for people with asthma that is not well controlled. People must have moderate to severe asthma despite using inhaled steroid and a long-acting beta-agonist (ICS-LABA) for at least 12 months.
It is , overseen by an independent and licensed medical staff.
Read the full clinical description
The study is being conducted to evaluate the effect of 3 dosing regimens of povorcitinib on pulmonary function
Who this study is looking for
In plain language, from the study's own rules. The study team confirms the full details with you — this isn't a final yes or no.
✅ You may be able to join if…
- •You have a doctor-diagnosed asthma and have been treated with medium- to high-dose ICS-LABA for at least 12 months before screening.
- •Your breathing test (pre-BD FEV1) is less than 80% of the predicted value at Visit 2.
- •Your past breathing test shows FEV1 improved by at least 12% and at least 200 mL after using a breathing treatment (post-BD reversibility).
- •You had at least 2 asthma flare-ups in the 12 months before screening (needing steroid pills, hospital care, or an emergency room visit), but not in the 4 weeks before screening.
- •Your ACQ-6 score is 1.5 or higher at screening. (ACQ-6 is a questionnaire that measures asthma control.)
🚫 You may not be able to join if…
- •You use asthma controller medicines other than ICS-LABA for maintenance.
- •You have had bronchial thermoplasty.
- •You currently smoke, have smoked with a history of at least 10 pack-years, or use vaping products (including electronic cigarettes).
- •You are pregnant, considering pregnancy, or breastfeeding.
- •You have certain other lung, blood, clotting, or heart/blood-vessel conditions (for example thrombocytopenia or blood clots), or you have had major heart/blood-vessel events.
Are you a good fit?
Simplified highlights. The study team always confirms the full details with you.
- ✓Have Asthma
- !Not for people who are pregnant or breastfeeding
What to expect, step by step
- 1
Usually a few weeks
The study team checks whether the study is a good fit for you, with a visit and sometimes lab tests. You can ask any questions before deciding.
- 2
Treatment
If you join and choose to continue, you receive the study treatment and are watched closely by medical staff.
- 3
Follow-up
After treatment, the team checks on your health and confirms the visit schedule with you. You can leave the study at any point.
Has this treatment been tested before?
Yes. This treatment has already been through earlier human studies for safety before reaching this stage.
What you need to know before you apply
What is this study testing?+
This study tests how well different doses of povorcitinib work and whether it is safe for people with asthma that is not well controlled. People must have moderate to severe asthma despite using inhaled steroid and a long-acting beta-agonist (ICS-LABA) for at least 12 months.
Is it safe? Who makes sure of that?+
This is a mid-stage study (Phase 2), looking at safety and whether the treatment works. Every study is reviewed and monitored by an independent ethics board (called an IRB) whose job is to protect participants, and care is overseen by licensed medical staff. You'll be told the known risks before you agree to anything, and you can stop at any time.
Will I get a placebo instead of the real treatment?+
Some studies compare a treatment against a placebo (an inactive version), and some don't. If this one does, the study team will explain your chances of receiving the active treatment before you decide. Nothing is hidden from you.
Do I have to stop taking my current medications?+
It depends on the study. Some let you stay on your current medications and some ask you to adjust them. Never stop a medication on your own — the study team will review everything with you first.
Does it cost anything? Will I be paid?+
The study treatment and study-related visits are provided at no cost to you. Some studies also pay for your time; the coordinator can tell you if this one does. You should never be asked to pay to take part.
Do I need insurance? Will anyone ask about my immigration status?+
No. You do not need health insurance to take part in a research study, and you will not be asked about your immigration status to join. Taking part is about whether you're a medical fit for the study.
What if English isn't my first language?+
You have the right to understand everything before you agree. Study sites can often provide materials or an interpreter in your language — you can ask the coordinator for one.
Is my information private?+
Yes. Your health information is only shared with the study sites you choose to be contacted by, and only to help match and enroll you. It is never sold, and you can ask us to delete it at any time.
Some requirements (like specific lab values or timing) are confirmed directly by the study team, not by us.
Source: ClinicalTrials.gov · NCT05851443 · Locations: Alabama · California · Florida · Georgia · Illinois · Michigan · New York · North Carolina · Pennsylvania · South Carolina · Texas