Depression

Mood and Thought Process Study

Recruiting · Providence, Rhode Island

Always free

Study care at no cost to you

For your time and travel

Many studies pay you back

Most need no insurance or papers

Legal status usually isn't required; we'll tell you each study's requirements

Interpreters available

Ask for your language

Your choice

Voluntary — you can stop anytime

What is this study?

This study tests two programs—Mindfulness-Based Cognitive Therapy (MBCT) and Wellness for Wellbeing—to see how they affect mood-related thinking and attention. You will do surveys, interviews, and computer tasks, and a staff member will confirm if you can join. The goal is to learn whether changes in mood symptoms relate to changes in thinking tasks over time.

It is , overseen by an independent and licensed medical staff.

Read the full clinical description

The primary objective for this project is to test whether affective executive functioning is a mechanism of action of mindfulness-based cognitive therapy and Wellness for Wellbeing. The main questions it aims to answer are: 1. Test the effect of MBCT vs. Wellness for Wellbeing on affective inhibition (i.e., emotionally valenced inhibition as measured via the affective Go/No Go task) using an RCT. 2. Test the effect of MBCT vs. Wellness for Wellbeing on (a) affective updating and (b) affective shifting. Outcomes will be measured with the affective n-Back and the affective Internal Switching Task, respectively. 3a) The investigators will examine whether depression symptom severity co-varies with change in affective executive functioning (i.e., affecting inhibition, shifting, and updating) over time. 3b) The investigators will examine whether compliance with treatment protocol (e.g., number of classes attended, amount of home practice) predicts endpoint executive functioning. Participants will complete surveys, interviews, and computer tasks, and will be randomized to either Mindfulness-Based Cognitive Therapy or Wellness for Wellbeing.

Who this study is looking for

In plain language, from the study's own rules. The study team confirms the full details with you — this isn't a final yes or no.

✅ You may be able to join if…

•Adults age 18 or older
•Able to do study tasks in English
•Have normal vision (or vision corrected to normal)
•Depression symptoms on the QIDS scale are between 5 and 15 (not severe)
•No current severe brain/behavior problems like psychosis that interfere with functioning, and no current mania symptoms

🚫 You may not be able to join if…

•Psychotic symptoms that interfere with functioning
•Hazardous alcohol or drug use (based on AUDIT/DUDIT scores described in the study)
•A change in psychiatric medicines within the last 4 weeks, or you started psychotherapy/other psychiatric treatment within the last 4 weeks
•Suicidal thoughts or behavior that need urgent safety help
•A history of MBCT or MBSR before, or thinking problems from mild cognitive impairment (MoCA score <26)

Are you a good fit?

Simplified highlights. The study team always confirms the full details with you.

✓Adults roughly 18–any age
✓Have Depression

!Some conditions may not be a fit: Fatty liver disease (NASH/MASH), Heart / cardiovascular disease, High blood pressure, High cholesterol, Kidney disease, COPD (chronic lung disease), Asthma, Anxiety

What to expect, step by step

1
Usually a few weeks
The study team checks whether the study is a good fit for you, with a visit and sometimes lab tests. You can ask any questions before deciding.
2
Treatment
If you join and choose to continue, you receive the study treatment and are watched closely by medical staff.
3
Follow-up
After treatment, the team checks on your health and confirms the visit schedule with you. You can leave the study at any point.

Has this treatment been tested before?

The study team can share what safety testing has been done so far.

What you need to know before you apply

What is this study testing?+

Is it safe? Who makes sure of that?+

This is a research study. Every study is reviewed and monitored by an independent ethics board (called an IRB) whose job is to protect participants, and care is overseen by licensed medical staff. You'll be told the known risks before you agree to anything, and you can stop at any time.

Will I get a placebo instead of the real treatment?+

Some studies compare a treatment against a placebo (an inactive version), and some don't. If this one does, the study team will explain your chances of receiving the active treatment before you decide. Nothing is hidden from you.

Do I have to stop taking my current medications?+

It depends on the study. Some let you stay on your current medications and some ask you to adjust them. Never stop a medication on your own — the study team will review everything with you first.

Does it cost anything? Will I be paid?+

Study-related care is provided at no cost to you. Some studies also pay for your time; the coordinator can tell you if this one does. You should never be asked to pay to take part.

Do I need insurance? Will anyone ask about my immigration status?+

No. You do not need health insurance to take part in a research study, and you will not be asked about your immigration status to join. Taking part is about whether you're a medical fit for the study.

What if English isn't my first language?+

You have the right to understand everything before you agree. Study sites can often provide materials or an interpreter in your language — you can ask the coordinator for one.

Is my information private?+

Yes. Your health information is only shared with the study sites you choose to be contacted by, and only to help match and enroll you. It is never sold, and you can ask us to delete it at any time.

Some requirements (like specific lab values or timing) are confirmed directly by the study team, not by us.

Source: ClinicalTrials.gov · NCT05585775 · Locations: Rhode Island