TrialPath — Discover research opportunities near you

What is this study?

This research study is creating a way to collect and store specimens and information from participants who may be at an increased risk of developing cancer, or has been diagnosed with an early phase of a cancer or a family member who has a family member with a precursor condition for cancer. * The objective of this study is to identify exposures as well as clinical, molecular, and pathological changes that can be used to predict early development of cancer, malignant transformation, and risks of progression to symptomatic cancer that can ultimately be fatal.

It is , overseen by an independent and licensed medical staff.

Read the full clinical description

This research study is creating a way to collect and store specimens and information from participants who may be at an increased risk of developing cancer, or has been diagnosed with an early phase of a cancer or a family member who has a family member with a precursor condition for cancer. * The objective of this study is to identify exposures as well as clinical, molecular, and pathological changes that can be used to predict early development of cancer, malignant transformation, and risks of progression to symptomatic cancer that can ultimately be fatal. * The ultimate goal is to identify novel markers of early detection and risk stratification to drive potential therapeutic approaches to intercept progression to cancer.

Who this study is looking for

In plain language, from the study's own rules. The study team confirms the full details with you — this isn't a final yes or no.

✅ You may be able to join if…

•People who may be at higher risk for cancer because of cancer gene changes or a family history of cancer risk
•People with a doctor-diagnosed “cancer predisposition syndrome” (example listed: neurofibromatosis, Fanconi anemia, ataxia-telangiectasia)
•People who are “exposed high risk,” including childhood or adult cancer survivors with treatment exposures that raise cancer risk and people with high exposure to group 1 IARC carcinogens
•People with pre-cancer or early precursor conditions (examples listed across organs, such as ductal/lobular carcinoma in situ for breast and Barrett’s esophagus for GI)
•Family members or healthy individuals in the at-risk groups described by the study

🚫 You may not be able to join if…

•There are no exclusion criteria listed for this study.

Are you a good fit?

Simplified highlights. The study team always confirms the full details with you.

✓People at increased cancer risk or with cancer precursor conditions are eligible (this study lists NASH/NAFL and cirrhosis).
✓Prior cancer history is allowed, including non-metastatic/localized cancers.
✓There are no stated exclusion criteria.

How this study is designed

The real details, in plain words. Tap the underlined words to learn what they mean.

✓Everyone in this study receives an active treatment — there is no placebo group.
•There are 4 groups in this study.

What to expect, step by step

· This study lasts about 260 weeks (~60 months)

1
Usually a few weeks
The study team checks whether the study is a good fit for you, with a visit and sometimes lab tests. You can ask any questions before deciding.
2
Treatment
About 260 weeks
If you join and choose to continue, you receive the study treatment and are watched closely by medical staff.
3
Follow-up
After treatment, the team checks on your health and confirms the visit schedule with you. You can leave the study at any point.

What's being tested

Other: Samples

Has this treatment been tested before?

The study team can share what safety testing has been done so far.

Who's running this study?

Sponsor

Dana-Farber Cancer Institute

Overseen by Sapna Syngal, MD

Every study is also reviewed by an independent that protects participants.

What you need to know before you apply

What is this study testing?+

This research study is creating a way to collect and store specimens and information from participants who may be at an increased risk of developing cancer, or has been diagnosed with an early phase of a cancer or a family member who has a family member with a precursor condition for cancer. * The objective of this study is to identify exposures as well as clinical, molecular, and pathological changes that can be used to predict early development of cancer, malignant transformation, and risks of progression to symptomatic cancer that can ultimately be fatal.

Is it safe? Who makes sure of that?+

This is a research study. Every study is reviewed and monitored by an independent ethics board (called an IRB) whose job is to protect participants, and care is overseen by licensed medical staff. You'll be told the known risks before you agree to anything, and you can stop at any time.

Will I get a placebo instead of the real treatment?+

Some studies compare a treatment against a placebo (an inactive version), and some don't. If this one does, the study team will explain your chances of receiving the active treatment before you decide. Nothing is hidden from you.

Do I have to stop taking my current medications?+

It depends on the study. Some let you stay on your current medications and some ask you to adjust them. Never stop a medication on your own — the study team will review everything with you first.

Does it cost anything? Will I be paid?+

Study-related care is provided at no cost to you. Some studies also pay for your time; the coordinator can tell you if this one does. You should never be asked to pay to take part.

Do I need insurance? Will anyone ask about my immigration status?+

No. You do not need health insurance to take part in a research study, and you will not be asked about your immigration status to join. Taking part is about whether you're a medical fit for the study.

What if English isn't my first language?+

You have the right to understand everything before you agree. Study sites can often provide materials or an interpreter in your language — you can ask the coordinator for one.

Is my information private?+

Yes. Your health information is only shared with the study sites you choose to be contacted by, and only to help match and enroll you. It is never sold, and you can ask us to delete it at any time.