Pharmacogenetics of Response to GLP1R Agonists
Recruiting · Lancaster, Pennsylvania
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Study care at no cost to you
For your time and travel
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Most need no insurance or papers
Legal status usually isn't required; we'll tell you each study's requirements
Interpreters available
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Your choice
Voluntary — you can stop anytime
What is this study?
Overweight/obese otherwise healthy volunteers will be recruited from the Old Order Amish population in Lancaster County, PA. Lancaster County, PA.
It is , overseen by an independent and licensed medical staff.
Read the full clinical description
Overweight/obese otherwise healthy volunteers will be recruited from the Old Order Amish population in Lancaster County, PA. Lancaster County, PA. Pharmacodynamic responses to GLP1R agonist will be assessed by conducting frequently sampled intravenous glucose tolerance tests (FSIGT) both before and after semaglutide for six weeks. The proposal proposes two specific aims: 1. Specific Aim #1. To identify genetic variants associated with effects of a GLP1R agonist to enhance glucose-stimulated first phase insulin secretion in the two FSIGTs (before and after administration of drug). 2. Specific Aim #2. To identify genetic variants associated with the effect of a GLP1R agonist to accelerate the rate of glucose disappearance as assessed in the two FSIGTs (before and after administration of drug). Genotyping will be conducted using a high-density array with comprehensive coverage of DNA sequence variants. In addition, the analysis will leverage a global imputation panel generated from 1,025 Amish individuals.
Who this study is looking for
In plain language, from the study's own rules. The study team confirms the full details with you — this isn't a final yes or no.
✅ You may be able to join if…
- •Be of Amish descent
- •Have a BMI of at least 27 kg/m²
- •Be able to stop other drugs/vitamins/supplements if the research team asks (so they don’t affect how you respond to semaglutide)
- •Have kidney and blood/liver/thyroid test results within the study’s limits (as judged by the study tests)
🚫 You may not be able to join if…
- •Be a woman of childbearing age who is sexually active (pregnancy risk)
- •Have diabetes (HbA1c over 6.5% or random glucose over 200 mg/dL)
- •Have a known allergy to semaglutide
- •Have kidney problems with eGFR below 60 mL/min/1.73 m²
- •Have thyroid/pituitary or liver/blood test results outside the limits (TSH too low/high, very low hematocrit, or AST/ALT more than 2× normal)
Are you a good fit?
Simplified highlights. The study team always confirms the full details with you.
- ✓Adults with BMI 27 or higher
- ✓Must be of Amish descent
- ✓No diabetes by stated glucose/A1c thresholds
- ✓No semaglutide allergy and meet key lab safety limits (kidney, blood, thyroid, liver)
- ✓Not able to change certain meds/supplements may not qualify
- !Some conditions may not be a fit: Kidney disease
- !May require a break from current GLP-1 medications
How this study is designed
The real details, in plain words. Tap the underlined words to learn what they mean.
- ✓Everyone in this study receives an active treatment — there is no placebo group.
What to expect, step by step
· This study lasts about 6 weeks- 1
Usually a few weeks
The study team checks whether the study is a good fit for you, with a visit and sometimes lab tests. You can ask any questions before deciding.
- 2
Treatment
About 6 weeksIf you join and choose to continue, you receive the study treatment and are watched closely by medical staff.
- 3
Follow-up
After treatment, the team checks on your health and confirms the visit schedule with you. You can leave the study at any point.
What's being tested
- Drug: Semaglutide Pen Injector [Ozempic]
Has this treatment been tested before?
This is an early-stage study. The treatment has gone through laboratory and preliminary testing before being studied in people here.
Who's running this study?
Sponsor
University of Maryland, Baltimore
Overseen by Amber L Beitelshees, PharmD
Every study is also reviewed by an independent that protects participants.
What you need to know before you apply
What is this study testing?+
Overweight/obese otherwise healthy volunteers will be recruited from the Old Order Amish population in Lancaster County, PA. Lancaster County, PA.
Is it safe? Who makes sure of that?+
This is an early study (Phase 1), focused mostly on safety. Every study is reviewed and monitored by an independent ethics board (called an IRB) whose job is to protect participants, and care is overseen by licensed medical staff. You'll be told the known risks before you agree to anything, and you can stop at any time.
Will I get a placebo instead of the real treatment?+
Some studies compare a treatment against a placebo (an inactive version), and some don't. If this one does, the study team will explain your chances of receiving the active treatment before you decide. Nothing is hidden from you.
I take a GLP-1 medication (like Ozempic or Wegovy). Can I still join?+
Maybe. This study may ask you to pause certain weight or diabetes medications for a period of time (a 'washout') before joining, or it may be looking for people not currently on them. The coordinator will review your medications with you — don't stop any medication on your own.
Does it cost anything? Will I be paid?+
The study treatment and study-related visits are provided at no cost to you. Some studies also pay for your time; the coordinator can tell you if this one does. You should never be asked to pay to take part.
Do I need insurance? Will anyone ask about my immigration status?+
No. You do not need health insurance to take part in a research study, and you will not be asked about your immigration status to join. Taking part is about whether you're a medical fit for the study.
What if English isn't my first language?+
You have the right to understand everything before you agree. Study sites can often provide materials or an interpreter in your language — you can ask the coordinator for one.
Is my information private?+
Yes. Your health information is only shared with the study sites you choose to be contacted by, and only to help match and enroll you. It is never sold, and you can ask us to delete it at any time.
Some requirements (like specific lab values or timing) are confirmed directly by the study team, not by us.
Source: ClinicalTrials.gov · NCT05071898 · Locations: Pennsylvania